2-氯-6-甲基-4-吡啶甲酸乙酯合成路线 （共 5 条）
反应条件
sulfuric acid T=0 - 80°C;
参考文献
Exelixis, Inc.
Patent: US2010/249071 A1, 2010 ;
Location in patent: Page/Page column 63-64 ;
反应条件
in ethanol; dichloromethane
参考文献
Zeneca Limited; Zeneca Pharma S.A.,
Patent: US5962458 A1, 1999 ;
US 5962458 A
反应条件
sulfuric acid in ethanol 2 h; Heating / reflux;
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 43 ;
US 6362336 B1
反应条件
1: With sodium t-butanolate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in tetrahydrofuran T=110°C; 42 h; Inert atmosphere; 2: With hydrogenchloride in water T=100°C; 18 h; 3: With sodium hydroxide in water
参考文献
US2011/46170 A1, ;
Page/Page column 18 ;
反应条件
acetic acid in tetrahydrofuran
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 43 ;
US 6362336 B1
