2-氯-6-甲基吡啶-4-羧酸甲酯合成路线 （共 19 条）
反应条件
in methanol; dichloromethane
参考文献
Zeneca Limited; Zeneca Pharma S.A.,
Patent: US5962458 A1, 1999 ;
US 5962458 A
反应条件
1: 1,2-dihydro-6-methyl-2-oxo-4-pyridinecarboxylic acid With trichlorophosphate 18 h; Reflux; 2: methanol T=20°C; 24 h; Cooling with ice bath;
参考文献
DU PREEZ, Jan Gysbert Hermanus; WENTZEL, Mauritz; KNOETZE, Steyn
Patent: WO2012/153253 A2, 2012 ;
Location in patent: Page/Page column 67 ;
反应条件
hydrogenchloride 6 h; Heating;
参考文献
Havas, Fabien; Danel, Mathieu; Galaup, Chantal; Tisnes, Pierre; Picard, Claude
Tetrahedron Letters, 2007 , vol. 48, # 6 p. 999 - 1002
参考文献
Dow AgroSciences LLC
Patent: US5968875 A1, 1999 ;
反应条件
in diethyl ether; ethanol
参考文献
MERCK FROSST CANADA LTD.
Patent: WO2008/46226 A1, 2008 ;
Location in patent: Page/Page column 38; 39 ;
WO 2008/046226 A1
反应条件
phosphorus pentachloride; trichlorophosphate
参考文献
Sperber et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 704,707
反应条件
phosphorus pentachloride; trichlorophosphate Behandeln des Reaktionsprodukts mit Methanol;
参考文献
Dulla, Balakrishna; Wan, Baojie; Franzblau, Scott G.; Kapavarapu, Ravikumar; Reiser, Oliver; Iqbal, Javed; Pal, Manojit
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4629 - 4635
反应条件
1: hydrogenchloride; water / 24 h / 115 °C / Inert atmosphere 2: trichlorophosphate / 18 h / Inert atmosphere; Reflux 3: 24 h / -5 - 20 °C / Inert atmosphere View Scheme
参考文献
Libermann et al.
Bulletin de la Societe Chimique de France, 1958 , p. 687,691
参考文献
Havas, Fabien; Leygue, Nadine; Danel, Mathieu; Mestre, Beatrice; Galaup, Chantal; Picard, Claude
Tetrahedron, 2009 , vol. 65, # 36 p. 7673 - 7686
反应条件
1: piperidine; ethanol 2: aqueous HCl 3: POCl3; PCl5 / Behandeln des Reaktionsprodukts mit Methanol View Scheme
参考文献
Libermann et al.
Bulletin de la Societe Chimique de France, 1958 , p. 687,691
