反-1,2-环丙烷二羧酸二乙酯合成路线 （共 15 条）
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With potassium tert-butylate in ethylene glycol dimethyl ether T=0°C; Wadsworth-Emmons cyclopropanation; 0.5 h; Inert atmosphere; 2: ethyl oxirane-2-carboxylate in ethylene glycol dimethyl ether T=40°C; Wadsworth-Emmons cyclopropanation; Inert atmosphereReflux;
参考文献
Riss, Patrick Johannes; Roesch, Frank
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 24 p. 4567 - 4574
反应条件
sodium hydride in toluene T=60°C; 1 h; to initiate the reaction MeOH;
参考文献
Ashton; Canning Meurer; Cantone; Field; Hannah; Karkas; Liou; Patel; Perry; Wagner; Walton; Tolman
Journal of Medicinal Chemistry, 1988 , vol. 31, # 12 p. 2304 - 2315
反应条件
in 1,2-dichloro-ethane T=20°C; Addition; Cyclopropanation; 0.5 h;
参考文献
Aggarwal, Varinder K.; Smitha, Helen W.; Hynd, George; Jones, Ray V.H.; Fieldhouse, Robin; Spey, Sharon E.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 19 p. 3267 - 3276
反应条件
ethanol; sulfuric acid; toluene
参考文献
Wiberg et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 4994,4997
Full Text Show Details
Blomquist; Longone
Journal of the American Chemical Society, 1959 , vol. 81, p. 2012,2015
反应条件
in acetonitrile 7 h;
参考文献
Kanai; Nishiguchi; Matsuda
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 6 p. 1592 - 1597
参考文献
Bailey,W.J.; Daly,J.J.
Journal of Organic Chemistry, 1964 , vol. 29, p. 1249 - 1251
参考文献
Payne,G.B.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3351 - 3355
反应条件
sodium hydride 1.) DMSO, 20 min, 2.) 1 h; Multistep reaction. Yields of byproduct given;
参考文献
Landor, Stephen R.; Landor, Phyllis, D.; Kalli, Michael
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2921 - 2926
反应条件
sodium hydride 1.) DMSO, 20 min, 2.) 1 h; Multistep reaction. Yields of byproduct given;
参考文献
Landor, Stephen R.; Landor, Phyllis, D.; Kalli, Michael
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2921 - 2926
反应条件
2: 457 °C View Scheme
参考文献
Bailey,W.J.; Daly,J.J.
Journal of Organic Chemistry, 1964 , vol. 29, p. 1249 - 1251
