1,1,1-三氟-4-甲基-3-戊烯-2-酮合成路线

参考文献

Reeves, Jonathan T.; Fandrick, Daniel R.; Tan, Zhulin; Song, Jinhua J.; Rodriguez, Sonia; Qu, Bo; Kim, Soojin; Niemeier, Oliver; Li, Zhibin; Byrne, Denis; Campbell, Scot; Chitroda, Ashish; Decroos, Phil; Fachinger, Thomas; Fuchs, Victor; Gonnella, Nina C.; Grinberg, Nelu; Haddad, Nizar; Jaeger, Burkhard; Lee, Heewon; Lorenz, Jon C.; Ma, Shengli; Narayanan, Bikshandarkoil A.; Nummy, Larry J.; Premasiri, Ajith; Roschangar, Frank; Sarvestani, Max; Shen, Sherry; Spinelli, Earl; Sun, Xiufeng; Varsolona, Richard J.; Yee, Nathan; Brenner, Michael; Senanayake, Chris H.
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 3616 - 3635

400-31-71,1,1-三氟-4-甲基-3-戊烯-2-酮

124445-98-3+

1073-06-9间溴氟苯+

1198785-52-24-(2-溴-4-氟苯基)-1,1,1-三氟-4-甲基-2-戊酮+

1429053-26-8+

496-69-52-溴-4-氟苯酚

参考文献

Journal of Organic Chemistry, , vol. 78, # 8 p. 3616 - 3635

38614-36-72-甲基-1-丙基溴化镁+

104863-67-4N-甲氧基-N-甲基-2,2,2-三氟乙酰胺

400-31-71,1,1-三氟-4-甲基-3-戊烯-2-酮

参考文献

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FANDRICK, Daniel, Robert; KUZMICH, Daniel; REEVES, Jonathan, Timothy; SONG, Jinhua, J.; TAN, Zhulin; LEE, Thomas
Patent: WO2010/141332 A2, 2010 ;
Location in patent: Page/Page column 14-15 ;

360-95-2N-三氟乙酰基吗啉+

38614-36-72-甲基-1-丙基溴化镁

400-31-71,1,1-三氟-4-甲基-3-戊烯-2-酮

参考文献

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FANDRICK, Daniel Robert; REEVES, Jonathan Timothy; SONG, Jinhua J.; TAN, Zhulin; QU, Bo; YEE, Nathan; RODRIGUEZ, Sonia
Patent: WO2010/141331 A2, 2010 ;
Location in patent: Page/Page column 14-15 ;

4068-48-8

400-31-71,1,1-三氟-4-甲基-3-戊烯-2-酮

参考文献

Gambaryan,N.P. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1965 , p. 1425 - 1427
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1965 , # 8 p. 1466 - 1469

33324-92-4+

104863-67-4N-甲氧基-N-甲基-2,2,2-三氟乙酰胺

400-31-71,1,1-三氟-4-甲基-3-戊烯-2-酮

参考文献

Riether, Doris; Harcken, Christian; Razavi, Hossein; Kuzmich, Daniel; Gilmore, Thomas; Bentzien, Joerg; Pack, Edward J.; Souza, Donald; Nelson, Richard M.; Kukulka, Alison; Fadra, Tazmeen N.; Zuvela-Jelaska, Ljiljana; Pelletier, Josephine; Dinallo, Roger; Panzenbeck, Mark; Torcellini, Carol; Nabozny, Gerald H.; Thomson, David S.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 18 p. 6681 - 6698

367-57-7三氟乙酰丙酮+

75-16-1甲基溴化镁

400-31-71,1,1-三氟-4-甲基-3-戊烯-2-酮+

367-58-8

参考文献

Henne; Hinkamp
Journal of the American Chemical Society, 1954 , vol. 76, p. 5147

400-31-71,1,1-三氟-4-甲基-3-戊烯-2-酮+

188132-02-7

609806-82-8

参考文献

Riether, Doris; Harcken, Christian; Razavi, Hossein; Kuzmich, Daniel; Gilmore, Thomas; Bentzien, Joerg; Pack, Edward J.; Souza, Donald; Nelson, Richard M.; Kukulka, Alison; Fadra, Tazmeen N.; Zuvela-Jelaska, Ljiljana; Pelletier, Josephine; Dinallo, Roger; Panzenbeck, Mark; Torcellini, Carol; Nabozny, Gerald H.; Thomson, David S.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 18 p. 6681 - 6698