2-溴-4-甲基噻唑-5-羧酸合成路线 （共 6 条）
参考文献
Barton, Anne; Breukelman, Stephen P.; Kaye, Perry T.; Meakins, G. Denis; Morgan, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 159 - 164
反应条件
tert.-butylnitrite; copper(I) bromide in acetonitrile 2 h; Heating / reflux;
参考文献
KALYPSYS, INC.
Patent: US2008/139558 A1, 2008 ;
Location in patent: Page/Page column 51 ;
US 20080139558 A1
反应条件
1: (i) aq. HBr, NaNO2, (ii) CuBr 2: NaOH / methanol View Scheme
参考文献
Abdel-Lateef,M.F.-A.; Eckstein,Z.
Roczniki Chemii, 1972 , vol. 46, p. 1647 - 1658
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 16 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH; XENON PHARMACEUTICALS INC
Patent: WO2008/24390 A2, 2008 ;
Location in patent: Page/Page column 83 ;
WO 2008/024390 A2
反应条件
1: 2-bromo-4-methyl-1,3-thiazole-5-carboxylic acid With 4-methyl-morpholine; isobutyl chloroformate in dichloromethane T=0 - 20°C; 2 h; 2: 4-methyl-morpholine in dichloromethane T=0 - 20°C; 4 h;
参考文献
NOVARTIS AG; XENON PHARMACEUTICALS INC.
Patent: WO2008/74835 A1, 2008 ;
Location in patent: Page/Page column 72 ;
WO 2008/074835 A1
参考文献
Barton, Anne; Breukelman, Stephen P.; Kaye, Perry T.; Meakins, G. Denis; Morgan, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 159 - 164
