5-溴-1-甲基-1H-吲哚-3-羧酸合成路线 （共 5 条）
反应条件
water; sodium hydroxide 2.5 h; Reflux;
参考文献
UNIVERSITE JOSEPH FOURIER; DENIS, Jean-Noël; JOLIVALT, Claude, Marcelle; MAURIN, Max, Maurin, Louis; JEANTY, Matthieu
Patent: WO2013/14102 A1, 2013 ;
Location in patent: Page/Page column 64; 65; 66 ;
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in tetrahydrofuran; water; tert-butyl alcohol T=20°C; 15 h;
参考文献
Duflos, Muriel; Nourrisson, Marie-Renee; Brelet, Jacques; Courant, Jacqueline; LeBaut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 6 p. 545 - 553
反应条件
1: 99.5 percent / POCl3 / 2 h / 10 °C 2: 98.5 percent / NaH / dimethylformamide / 2 h / 20 °C 3: 80 percent / NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol; tetrahydrofuran; H2O / 15 h / 20 °C View Scheme
参考文献
UNIVERSITE JOSEPH FOURIER; DENIS, Jean-Noël; JOLIVALT, Claude, Marcelle; MAURIN, Max, Maurin, Louis; JEANTY, Matthieu
Patent: WO2013/14102 A1, 2013 ;
反应条件
1: 98.5 percent / NaH / dimethylformamide / 2 h / 20 °C 2: 80 percent / NaClO2; NaH2PO4; 2-methyl-2-butene / 2-methyl-propan-2-ol; tetrahydrofuran; H2O / 15 h / 20 °C View Scheme
参考文献
Duflos, Muriel; Nourrisson, Marie-Renee; Brelet, Jacques; Courant, Jacqueline; LeBaut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 6 p. 545 - 553
反应条件
1: N,N-dimethyl-formamide / 3.5 h / 0 °C / |Inert atmosphere 2: sodium hydroxide; water / 2.5 h / |Reflux View Scheme
参考文献
UNIVERSITE JOSEPH FOURIER; DENIS, Jean-Noël; JOLIVALT, Claude, Marcelle; MAURIN, Max, Maurin, Louis; JEANTY, Matthieu
Patent: WO2013/14102 A1, 2013 ;
