2-乙酰-7-羟基苯并呋喃合成路线 （共 17 条）
反应条件
aluminium trichloride in xylene 3 h; Heating;
参考文献
Papadaki-Valiraki; Todoulou; Filippatos; Tsotinis; Ikeda; De Clercq
Arzneimittel-Forschung/Drug Research, 1993 , vol. 43, # 12 p. 1363 - 1366
反应条件
1: 84 percent / K2CO3 / acetone 2: 57 percent / AlCl3 / xylene / 3 h / Heating View Scheme
参考文献
Papadaki-Valiraki; Todoulou; Filippatos; Tsotinis; Ikeda; De Clercq
Arzneimittel-Forschung/Drug Research, 1993 , vol. 43, # 12 p. 1363 - 1366
反应条件
1: 74 percent / ClSO3H / 1.5 h / 25 °C 2: 92 percent / H2O / 1 h / 70 °C 3: 71 percent / HNO3 / aq. H2SO4 / 0.17 h / 50 °C 4: 1N aq. NaOH / methanol / 25 °C 6: NaOH / H2O View Scheme
参考文献
Ohishi; Mukai; Nagahara; Yajima; Kajikawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2398 - 2405
反应条件
potassium carbonate in acetone T=54°C; 2 h;
参考文献
Ando, Kumiko; Tsuji, Eriko; Ando, Yuko; Kuwata, Noriko; Kunitomo, Jun-Ichi; Yamashita, Masayuki; Ohta, Shunsaku; Kohno, Shigekatsu; Ohishi, Yoshitaka
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 4 p. 625 - 635
反应条件
potassium carbonate in acetone T=54°C; 2 h;
参考文献
Ohishi; Mukai; Nagahara; Yajima; Kajikawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2398 - 2405
反应条件
1: NBS 2: K2CO3 / acetone View Scheme
参考文献
Ando, Kumiko; Tsuji, Eriko; Ando, Yuko; Kunitomo, Jun-Ichi; Yamashita, Masayuki; Ohta, Shunsaku; Nabe, Takeshi; Kohno, Shigekatsu; Yokomizo, Takehiko; Shimizu, Takao; Ohishi, Yoshitaka
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3427 - 3431
反应条件
1: 74 percent / ClSO3H / 1.5 h / 25 °C
2: 92 percent / H2O / 1 h / 70 °C
3: 71 percent / HNO3 / aq. H2SO4 / 0.17 h / 50 °C
4: 1N aq. NaOH / methanol / 25 °C
6: NaOH / H2O
View Scheme
参考文献
Ohishi; Mukai; Nagahara; Yajima; Kajikawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2398 - 2405
反应条件
aluminium trichloride; bromine in dichloromethane
T=26°C; 3 h;
参考文献
Ando, Kumiko; Tsuji, Eriko; Ando, Yuko; Kunitomo, Jun-Ichi; Kobayashi, Reina; Yokomizo, Takehiko; Shimizu, Takao; Yamashita, Masayuki; Ohta, Shunsaku; Nabe, Takeshi; Kohno, Shigekatsu; Ohishi, Yoshitaka
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 11 p. 2129 - 2139
反应条件
1: 93.3 percent / AlCl3; Br2 / CH2Cl2 / 3 h / 26 °C
2: 56.5 percent / K2CO3 / acetone / 2 h / 54 °C
View Scheme
参考文献
Ando, Kumiko; Tsuji, Eriko; Ando, Yuko; Kunitomo, Jun-Ichi; Yamashita, Masayuki; Ohta, Shunsaku; Nabe, Takeshi; Kohno, Shigekatsu; Yokomizo, Takehiko; Shimizu, Takao; Ohishi, Yoshitaka
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3427 - 3431
反应条件
potassium carbonate in acetone
T=56°C; 8 h;
参考文献
The New Industry Research Organization
Patent: EP1627873 A1, 2006 ;
Location in patent: Page/Page column 41; 42 ;
EP 1627873 A1
