3,4-二氨基噻吩并[2,3-b]噻吩-2,5-二羧酸二乙酯合成路线 （共 4 条）
反应条件
sodium ethanolate in ethanol; dichloromethane
T=20°C; 0.5 h;
参考文献
Liu, Ming-Guo; Hu, Yang-Gen; Ding, Ming-Wu
Tetrahedron, 2008 , vol. 64, # 38 p. 9052 - 9059
反应条件
1: carbon disulfide; malononitrile With potassium carbonate in N,N-dimethyl-formamide
0.5 h;
2: ethyl bromoacetate in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Comel; Kirsch
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1167 - 1171
反应条件
tetrabutylammomium bromide; potassium carbonate in benzene
参考文献
El-Shafei, A. K.; El-Saghier, A. M. M.; Sultan, A.; Soliman, A. M.
Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 72, # 1-4 p. 73 - 80
反应条件
1.1: 75 percent H2SO4; sodium nitrite / H2O / 0.5 h / 0 °C
1.2: 65 percent / 50 percent hypophosphorus acid / H2O / 2 h / 20 °C
2.1: aq. NaOH / ethanol / 2 h / Heating
3.1: quinoline; copper bronze / 1 h / Heating
View Scheme
参考文献
Comel; Kirsch
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1167 - 1171
