2-氨基-3-苄基-5-(4-甲氧基苯基)吡嗪合成路线 （共 22 条）
反应条件
1: pyridinium chloride 2: 36percent aq. HCl / ethanol / 4 h / 80 °C View Scheme
参考文献
Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi; Ohashi, Mamoru; Ohmiya, Yoshihiro; Tsuji, Frederick I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1607 - 1612
反应条件
hydrogenchloride in ethanol; water Reflux;
参考文献
UNIVERSITA DEGLI STUDI DI SIENA; GIULIANI, Germano; CAPPELLI, Andrea; VOMERO, Salvatore; ANZINI, Maurizio
Patent: WO2011/7314 A1, 2011 ;
Location in patent: Page/Page column 38 ;
反应条件
1: pyridinium chloride 2: 36percent aq. HCl / ethanol / 4 h / 80 °C View Scheme
参考文献
Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi; Ohashi, Mamoru; Ohmiya, Yoshihiro; Tsuji, Frederick I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1607 - 1612
反应条件
bis(benzonitrile)palladium(II) dichloride; sodium carbonate; 1,4-di(diphenylphosphino)-butane in ethanol; water; toluene
4 h; Heating;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Organic Preparations and Procedures International, 2001 , vol. 33, # 5 p. 477 - 485
参考文献
Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi; Ohashi, Mamoru; Ohmiya, Yoshihiro; Tsuji, Frederick I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1607 - 1612
反应条件
1: 69 percent / hydroxybenzotriazole; EDC; pyridine / CH2Cl2 / 15 h / 20 °C
2: CH2Cl2 / 1.5 h / 0 °C
3: NH2OH*HCl; Na2CO3 / ethanol; H2O / 19 h / 20 - 70 °C
4: H2 / Raney-Ni W2 / methanol / 3 h / 20 °C / atmospheric pressure
5: pyridine / 1 h / 20 °C
6: 91 percent / NaH / tetrahydrofuran / 2 h / 20 °C
7: 85 percent / i-Pr2NEt / CH2Cl2 / 2 h / 0 °C
8: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
9: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
反应条件
sulfuric acid
T=0°C; 0.333333 h;
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
反应条件
1: H2 / Raney-Ni W2 / methanol / 3 h / 20 °C / atmospheric pressure
2: pyridine / 1 h / 20 °C
3: 91 percent / NaH / tetrahydrofuran / 2 h / 20 °C
4: 85 percent / i-Pr2NEt / CH2Cl2 / 2 h / 0 °C
5: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
6: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
