2-氨基-3-苄基-5-(4-甲氧基苯基)吡嗪合成路线 （共 22 条）
反应条件
1: CH2Cl2 / 1.5 h / 0 °C
2: NH2OH*HCl; Na2CO3 / ethanol; H2O / 19 h / 20 - 70 °C
3: H2 / Raney-Ni W2 / methanol / 3 h / 20 °C / atmospheric pressure
4: pyridine / 1 h / 20 °C
5: 91 percent / NaH / tetrahydrofuran / 2 h / 20 °C
6: 85 percent / i-Pr2NEt / CH2Cl2 / 2 h / 0 °C
7: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
8: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
反应条件
1: 89 percent / tetra-n-butylammonium tribromide; pyridine / CHCl3 / 0.75 h / 20 °C
2: 88 percent / (PhCN)2PdCl2; 1,4-bis(diphenylphosphino)butane; Na2CO3 / toluene; ethanol; H2O / 4 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Mattingly, Phillip G.; Pan, You; Reddy, Rajarathnam E.
Organic Preparations and Procedures International, 2001 , vol. 33, # 5 p. 477 - 485
反应条件
1: 43 percent / pyridine, TiCl4 / 2.75 h / -20 - 80 °C
2: H2 / Raney nickel W2 / ethanol / 96 h
View Scheme
参考文献
Usami, Ken; Isobe, Minoru
Tetrahedron, 1996 , vol. 52, # 37 p. 12061 - 12090
反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / hexane / 0.5 h / 0 - 60 °C
1.2: 0.5 h / 0 °C
2.1: pyridine; tetra-n-butylammonium tribromide / chloroform / 1 h / 20 °C
3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene; ethanol / Inert atmosphere; Reflux
View Scheme
参考文献
UNIVERSITA DEGLI STUDI DI SIENA; GIULIANI, Germano; CAPPELLI, Andrea; VOMERO, Salvatore; ANZINI, Maurizio
Patent: WO2011/7314 A1, 2011 ;
反应条件
1: pyridine / 1 h / 20 °C
2: 91 percent / NaH / tetrahydrofuran / 2 h / 20 °C
3: 85 percent / i-Pr2NEt / CH2Cl2 / 2 h / 0 °C
4: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
5: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
反应条件
1: 85 percent / i-Pr2NEt / CH2Cl2 / 2 h / 0 °C
2: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
3: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
反应条件
1: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
2: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
反应条件
1: 91 percent / NaH / tetrahydrofuran / 2 h / 20 °C
2: 85 percent / i-Pr2NEt / CH2Cl2 / 2 h / 0 °C
3: 89 percent / K3PO4; PPh3; Pd(dba)2 / dioxane / 3 h / 80 °C
4: 49 percent / H2SO4 / 0.33 h / 0 °C
View Scheme
参考文献
Kuse, Masaki; Kondo, Nobuhiro; Ohyabu, Yuki; Isobe, Minoru
Tetrahedron, 2004 , vol. 60, # 4 p. 835 - 840
反应条件
1: pyridine, TiCl4
2: H2 / Raney-Ni
View Scheme
参考文献
Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi; Ohashi, Mamoru; Ohmiya, Yoshihiro; Tsuji, Frederick I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1607 - 1612
反应条件
1: pyridine, TiCl4
2: H2 / Raney-Ni
View Scheme
参考文献
Qi, Chen Feng; Gomi, Yasushiro; Hirano, Takashi; Ohashi, Mamoru; Ohmiya, Yoshihiro; Tsuji, Frederick I.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1607 - 1612
