2-氨基-1,3,4-噻二唑合成路线 （共 44 条）
反应条件
triethylamine in diethyl ether 2 h;
参考文献
Heitmeier,D.E.; Gray,A.P.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 288 - 293
反应条件
copper monoiodide; isopentyl nitrite in tetrahydrofuran; ethyl acetate
参考文献
Eisai Co., Ltd.
Patent: US6599917 B1, 2003 ;
参考文献
Ahad, Ali Md.; Zuohe, Song; Du-Cuny, Lei; Moses, Sylvestor A.; Zhou, Li Li; Zhang, Shuxing; Powis, Garth; Meuillet, Emmanuelle J.; Mash, Eugene A.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2046 - 2054
反应条件
acetic acid in water
参考文献
Ermili,A.; Cortese,I.
Farmaco, Edizione Scientifica, 1967 , vol. 22, p. 393 - 401
反应条件
Hydrolyse des Reaktionsprodukts;
参考文献
Roblin et al.
Journal of the American Chemical Society, 1940 , vol. 62, p. 2002,2003
Journal of the American Chemical Society, 1942 , vol. 64, p. 567,568
Full Text Show Details
Guha; Das-Gupta
Journal of the Indian Chemical Society, 1945 , vol. 22, p. 79
Full Text Show Details
CIBA
Patent: CH229083 , 1938 ;
反应条件
Reduktion des Reaktionsprodukts mit Eisen und wss. HCl;
参考文献
Schering Corp.
Patent: US2476655 , 1941 ;
反应条件
hydrogen bromide; copper; sodium nitrite
参考文献
Bristol-Myers Company
Patent: US3946000 A1, 1976 ;
反应条件
in 1,4-dioxane
1 h; Heating;
参考文献
Rachlin, Schneur; Bramm, E.; Ahnfelt-Ronne, I.; Arrigoni-Martelli, E.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 13 - 20
反应条件
T=20 - 25°C; 0.416667 h;
参考文献
Azev, Yu. A.; Vereshchagina, N. N.; Postovskii, I. Ya.; Pidemskii, E. L.; Goleneva, A. F.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 11 p. 789 - 791
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 11 p. 50 - 53
反应条件
in benzene
2 h; Heating;
参考文献
Zee-Cheng,K.Y.; Cheng,C.C.
Journal of Medicinal Chemistry, 1979 , vol. 22, p. 28 - 32
