3-环己基-L-丙氨酸甲酯合成路线 （共 8 条）
参考文献
Athena Neurosciences, Inc.; Eli Lilly and Company
Patent: US6096782 A1, 2000 ;
反应条件
in methanol; toluene
参考文献
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Patent: US5866685 A1, 1999 ;
反应条件
1: H2 / Pt/C / acetic acid
2: SOCl2
View Scheme
参考文献
Plata; Leanna; Morton
Tetrahedron Letters, 1991 , vol. 32, # 30 p. 3623 - 3626
反应条件
1.1: 91 percent / aq. CAN / acetonitrile / 1 h / 20 °C
2.1: aq. HCl / Heating
2.2: aq. HCl / 2 h / Heating
View Scheme
参考文献
Bull; Davies; Garner; O'Shea
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 24 p. 3281 - 3287
参考文献
Gregory; Jones; Morley
Journal of the Chemical Society. Perkin transactions 1, 1968 , vol. 5, p. 531 - 540
Title/Abstract Full Text View citing articles Show Details
Plata; Leanna; Morton
Tetrahedron Letters, 1991 , vol. 32, # 30 p. 3623 - 3626
反应条件
1: (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione With hydrogenchloride
Heating;
2: methanol With hydrogenchloride
2 h; Heating; Further stages.;
参考文献
Bull; Davies; Garner; O'Shea
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 24 p. 3281 - 3287
反应条件
Alkaline conditions;
参考文献
Falini, Giuseppe; Gualandi, Andrea; Savoia, Diego
Synthesis, 2009 , # 14 art. no. Z02609SS, p. 2440 - 2446
反应条件
hydrogenchloride
0.5 h; Heating;
参考文献
Bull; Davies; Garner; O'Shea
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 24 p. 3281 - 3287
