2,4-二羟基喹啉-3-甲酸乙酯合成路线 （共 39 条）
反应条件
sodium hydride in N,N-dimethyl-formamide 5 h; Reflux;
参考文献
Pudlo, Marc; Luzet, Vincent; Ismaili, Lhassane; Tomassoli, Isabelle; Iutzeler, Anne; Refouvelet, Bernard
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2496 - 2507
反应条件
sodium ethanolate in ethanol T=20 - 140°C; 14.5 h;
参考文献
Ohashi, Tomohiro; Oguro, Yuya; Tanaka, Toshio; Shiokawa, Zenyu; Shibata, Sachio; Sato, Yoshihiko; Yamakawa, Hiroko; Hattori, Harumi; Yamamoto, Yukiko; Kondo, Shigeru; Miyamoto, Maki; Tojo, Hideaki; Baba, Atsuo; Sasaki, Satoshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 18 p. 5496 - 5506
反应条件
sodium hydroxide; sodium tetrahydroborate; hydrogen; palladium on activated charcoal in 1,4-dioxane T=20°C; 0.5 h;
参考文献
Jung, Jae-Chul; Baek, Shin; Park, Oee-Sook
Farmaco, 2001 , vol. 56, # 9 p. 664 - 676
反应条件
sodium in ethanol T=145°C; 19 h;
参考文献
Reisch, Johannes; Salehi-Artimani, Reza A.; Bathe, Andreas; Mueller, Michael
Monatshefte fuer Chemie, 1988 , vol. 119, p. 781 - 792
反应条件
potassium hydroxide 0.5 h;
参考文献
Ukrainets, I. V.; Bezuglyi, P. A.; Treskach, V. I.; Turov, A. V.; Slobodzyan, S. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 5 p. 534 - 538
Khimiya Geterotsiklicheskikh Soedinenii, Sbornik, 1992 , # 5 p. 636 - 639
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphereSealed tube; 2: 2-methyl-(4H)3,1-benzoxazin-4-one in tetrahydrofuran; mineral oil T=70°C; 0.166667 h; Inert atmosphereSealed tubeMicrowave irradiation;
参考文献
Prousis, Kyriakos C.; Tzani, Andromachi; Avlonitis, Nicolaos; Calogeropoulou, Theodora; Detsi, Anastasia
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1313 - 1321
反应条件
ethanol; sodium hydride in benzene Cyclization; 5 h; Heating;
参考文献
Mitsos, Christos; Zografos, Alexandros; Igglessi-Markopoulou, Olga
Heterocycles, 1999 , vol. 51, # 7 p. 1543 - 1561
反应条件
1: 2-amino-benzoic acid methyl ester; malonoyl dichloride With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C; 5 h; Inert atmosphere; 2: sodium ethanolate With hydrogenchloride in ethanol; water T=20°C; Inert atmosphere;
参考文献
Carrer, Amandine; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 10 p. 2044 - 2054
反应条件
potassium carbonate in dimethyl sulfoxide T=60°C; Alkylation; deacetylation; 15 h;
参考文献
Ukrainets; Taran; Gorokhova; Gorlacheva; Bezuglyi; Turov
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 8 p. 952 - 959
反应条件
1.1: SOCl2; urea / toluene / 3 h / 100 °C 2.1: Mg; EtOH / CCl4; toluene / 2 h 2.2: toluene; CCl4 / 0.5 h / 20 °C 3.1: aq. NaOH / 10 percent Pd/C / dioxane / 0.33 h / 20 °C 3.2: 70 percent / aq. NaBH4 / dioxane / 0.5 h / 20 °C View Scheme
参考文献
Jung; Park
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 61 - 67
