2,4-二羟基喹啉-3-甲酸乙酯合成路线 （共 39 条）
反应条件
1.1: Mg; EtOH / CCl4; toluene / 2 h 1.2: toluene; CCl4 / 0.5 h / 20 °C 2.1: aq. NaOH / 10 percent Pd/C / dioxane / 0.33 h / 20 °C 2.2: 70 percent / aq. NaBH4 / dioxane / 0.5 h / 20 °C View Scheme
参考文献
Jung; Park
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 61 - 67
反应条件
sodium methylate in ethanol 0.5 h;
参考文献
Rowley, Michael; Leeson, Paul D.; Stevenson, Graeme I.; Moseley, Angela M.; Stansfield, Ian; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3386 - 3396
反应条件
1: Et3N, DMAP / CH2Cl2 / 0 °C 2: NaOMe / ethanol / 0.5 h View Scheme
参考文献
Rowley, Michael; Leeson, Paul D.; Stevenson, Graeme I.; Moseley, Angela M.; Stansfield, Ian; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3386 - 3396
反应条件
sodium hydroxide; sodium carbonate 2 h; Ambient temperature;
参考文献
Detsi, Anastasia; Bardakos, Vassilios; Markopoulos, John; Igglessi-Markopoulou, Olga
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 24 p. 2909 - 2913
反应条件
1: With sodium hydride in toluene 2: Acidic conditions;
参考文献
Hajdok, Szilvia; Conrad, Juergen; Leutbecher, Heiko; Strobel, Sabine; Schleid, Thomas; Beifuss, Uwe
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7230 - 7237
反应条件
1: 91 percent / pyridine / 2 h / 20 °C 2: 83 percent / sodium hydride in oil / benzene / 2 h / 20 °C 3: 95 percent / sodium hydride in oil; ethanol / benzene / 5 h / Heating View Scheme
参考文献
Prousis, Kyriakos C.; Tzani, Andromachi; Avlonitis, Nicolaos; Calogeropoulou, Theodora; Detsi, Anastasia
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1313 - 1321
反应条件
1: 83 percent / sodium hydride in oil / benzene / 2 h / 20 °C 2: 95 percent / sodium hydride in oil; ethanol / benzene / 5 h / Heating View Scheme
参考文献
Mitsos, Christos; Zografos, Alexandros; Igglessi-Markopoulou, Olga
Heterocycles, 1999 , vol. 51, # 7 p. 1543 - 1561
反应条件
1: 94 percent / pyridine / acetone / 5 h / Ambient temperature 2: 95 percent / aq. KOH / 0.5 h View Scheme
参考文献
Ukrainets, I. V.; Bezuglyi, P. A.; Treskach, V. I.; Turov, A. V.; Slobodzyan, S. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992 , vol. 28, # 5 p. 534 - 538
Khimiya Geterotsiklicheskikh Soedinenii, Sbornik, 1992 , # 5 p. 636 - 639
反应条件
sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in ethanol
参考文献
Zhang, Lijuan; Luo, Yu; Yu, Shanbao; Lu, Wei
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 5 p. 1254 - 1256,3
反应条件
zinc(II) chloride in ethanol ring expansion; Heating;
参考文献
Fray, M. Jonathan; Bull, David J.; Carr, Christopher L.; Stobie, Alan
Medicinal Chemistry Research, 1996 , vol. 6, # 9 p. 581 - 592
