1-[(三甲基硅基)乙炔]-3,5-二甲氧基苯合成路线 （共 6 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 0.0833333 h;
参考文献
Gehringer, Lionel; Bourgogne, Cyril; Guillon, Daniel; Donnio, Bertrand
Journal of the American Chemical Society, 2004 , vol. 126, # 12 p. 3856 - 3867
反应条件
copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride
T=20°C; Inert atmosphere;
参考文献
KENT STATE UNIVERSITY; SUMMA HEALTH SYSTEM
Patent: WO2008/157745 A1, 2008 ;
Location in patent: Page/Page column 18 ;
反应条件
1.1: aq. HCl; NaNO2 / 0 °C
1.2: 50 percent / aq. KI / 20 °C
2.1: 85 percent / Pd(PPh3)2Cl2; CuI; PPh3 / triethylamine / 48 h / 50 °C
View Scheme
参考文献
Gehringer, Lionel; Bourgogne, Cyril; Guillon, Daniel; Donnio, Bertrand
Journal of the American Chemical Society, 2004 , vol. 126, # 12 p. 3856 - 3867
反应条件
1: potassium iodide / water / 20 °C
2: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 20 °C / Inert atmosphere
View Scheme
参考文献
KENT STATE UNIVERSITY; SUMMA HEALTH SYSTEM
Patent: WO2008/157745 A1, 2008 ;
反应条件
tris-(dibenzylideneacetone)dipalladium(0); Me3SnNMe2; triphenylphosphine in toluene
Sonogashira coupling; 8 h; Inert atmosphereReflux;
参考文献
Cai, Liangzhen; Yang, Dujuan; Sun, Zhonghua; Tao, Xiaochun; Cai, Lisheng; Pike, Victor W.
Chinese Journal of Chemistry, 2011 , vol. 29, # 5 p. 1059 - 1062
反应条件
1: potassium fluoride; methanol / 2 h / 20 °C
2: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 6 h / 20 °C / Inert atmosphere
View Scheme
参考文献
KENT STATE UNIVERSITY; SUMMA HEALTH SYSTEM
Patent: WO2008/157745 A1, 2008 ;
