(3S)-3-[[(1,1-二甲基乙氧基)羰基]氨基]-2-氧代-4-苯基丁烷-二甲基氧化硫合成路线 （共 10 条）
反应条件
1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 2: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 3: 96 percent / t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 16 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1629 - 1633
反应条件
1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 2: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 3: 96 percent / t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 16 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1629 - 1633
反应条件
1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 2: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme
参考文献
Wang, Dengjin; Schwinden, Mark D.; Radesca, Lilian; Patel, Bharat; Kronenthal, David; Huang, Ming-Hsing; Nugent, William A.
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1629 - 1633
反应条件
1: trimethyl-oxo-sulfonium iodide With potassium tert-butylate in tetrahydrofuran
T=90°C; 2 h;
2: C19H27NO5 in tetrahydrofuran
T=-20°C;
参考文献
CODEXIS, INC.; COLLIER, Steven, J.; LIANG, Jack
Patent: WO2010/117796 A2, 2010 ;
Location in patent: Page/Page column 38 ;
反应条件
1: trimethyl-oxo-sulfonium iodide With potassium tert-butylate in tetrahydrofuran
T=90°C; 2 h;
2: C18H28NO7P in tetrahydrofuran
T=-20°C;
参考文献
CODEXIS, INC.; COLLIER, Steven, J.; LIANG, Jack
Patent: WO2010/117796 A2, 2010 ;
Location in patent: Page/Page column 38 ;
反应条件
1: trimethyl-oxo-sulfonium iodide With potassium tert-butylate in tetrahydrofuran
T=90°C; 2 h;
2: Boc-Phe-O-COO-isoBu in tetrahydrofuran
T=0°C; 2.75 h; Product distribution / selectivity;
参考文献
CODEXIS, INC.; COLLIER, Steven, J.; LIANG, Jack
Patent: WO2010/117796 A2, 2010 ;
Location in patent: Page/Page column 6; 35 ;
反应条件
1: trimethyl sulfoxonium chloride With potassium tert-butylate in tetrahydrofuran
T=90°C; 2 h;
2: C21H23NO6 in tetrahydrofuran
T=-20°C; 4 h;
参考文献
CODEXIS, INC.; COLLIER, Steven, J.; LIANG, Jack
Patent: WO2010/117796 A2, 2010 ;
Location in patent: Page/Page column 36; 37 ;
反应条件
1: trimethyl sulfoxonium chloride With potassium tert-butylate in tetrahydrofuran
2 h; Reflux;
2: C18H21N3O5; (2S)-2-[N-(tert-butoxycarbonyl)amino]-1-imidazol-1-yl-3-phenylpropan-1-one in tetrahydrofuran
T=0°C; 4.16667 h;
参考文献
CODEXIS, INC.; COLLIER, Steven, J.; LIANG, Jack
Patent: WO2010/117796 A2, 2010 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
1: trimethyl sulfoxonium chloride With potassium tert-butylate in tetrahydrofuran
2 h; Reflux;
2: C17H21N3O3; C18H21N3O5 in tetrahydrofuran
T=0°C; 4.16667 h;
参考文献
CODEXIS, INC.; COLLIER, Steven, J.; LIANG, Jack
Patent: WO2010/117796 A2, 2010 ;
Location in patent: Page/Page column 39; 40 ;
反应条件
1: trimethyl-oxo-sulfonium iodide With potassium tert-butylate in tetrahydrofuran
2 h; Heating;
2: N-tert-butyloxycarbonyl-L-phenylalanine p-nitrophenyl ester in tetrahydrofuran
T=0°C; 4 h;
参考文献
Wang, Dengjin; Schwinden, Mark D.; Radesca, Lilian; Patel, Bharat; Kronenthal, David; Huang, Ming-Hsing; Nugent, William A.
Journal of Organic Chemistry, 2004 , vol. 69, # 5 p. 1629 - 1633
