1: 4-piperidone-monohydrite, hydrochloride With sodium carbonate
2: bromomethyl-cyclopropane in acetonitrile
T=65°C;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
1: potassium hydroxide / methanol / 5.5 h / Reflux
2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h
View Scheme
参考文献
Conway, Richard J.; Valant, Celine; Christopoulos, Arthur; Robertson, Alan D.; Capuano, Ben; Crosby, Ian T.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2560 - 2564