[(1R)-1-氰基-2-苯基乙基]氨基甲酸叔丁酯合成路线 （共 3 条）
反应条件
TEA; trifluoroacetic anhydride in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Donkor, Isaac O.; Han, Jie; Zheng, Xiaozhang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 72 - 79
反应条件
N-(o-trifluoromethylbenzyl)quininium bromide; potassium carbonate in toluene
T=-20°C; 42 h; Title compound not separated from byproducts;
参考文献
Herrera, Raquel P.; Sgarzani, Valentina; Bernardi, Luca; Fini, Francesco; Pettersen, Daniel; Ricci, Alfredo
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9869 - 9872
反应条件
1: TEA / tetrahydrofuran / 0.5 h / -10 °C
2: NH3 / tetrahydrofuran / 1.5 h / 0 °C
3: 92 percent / TEA; (CF3CO)2O / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Donkor, Isaac O.; Han, Jie; Zheng, Xiaozhang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 72 - 79
