salicylaldehyde; acetic acid in methanol T=65°C; pH=5; 143 h; Product distribution / selectivity;

<b>Multi-step reaction with 2 steps<br /> </b>1: 60 percent / Na/Hg / ethanol<br />2: RP₁₈-HPLC resolution<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: KOH / ethanol; H₂O / 2.5 h / 20 &deg;C<br />2: 60 percent / Na/Hg / ethanol<br />3: RP₁₈-HPLC resolution<br /> <br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '172966', constants.ctx, '0')">3-(3-indolyl)-2-oxopropanoic acid</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />pH=12;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '3568341', constants.ctx, '0')">sodium 2-oxopropanoate</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=20&deg;C;&nbsp;pH=9;&nbsp;4&nbsp;h;&nbsp;<br />Stage #3: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1720249', constants.ctx, '0')">(R)-alanine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '234749', constants.ctx, '0')">pyridoxal 5'-phosphate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=33&deg;C;&nbsp;24&nbsp;h;&nbsp;&nbsp;Product distribution / selectivity;&nbsp;<br /> <br /> &nbsp;