2-(3-苯基-1,2,4-恶二唑-5-基)苯胺合成路线 (共 12 条)
反应条件
potassium hydroxide in ethanol
4 h; Heating;
参考文献
Corsaro, Antonino; Chiacchio, Ugo; Caramella, Pierluigi; Purrello, Giovanni
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 949 - 952
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
6 h; Inert atmosphereReflux;
参考文献
Draghici, Bogdan; El-Gendy, Bahaa El-Dien M.; Katritzky, Alan R.
Synthesis, 2012 , vol. 44, # 4 p. 547 - 550
反应条件
1: 11percent aq. sodium hypochlorite
2: CH2Cl2 / 24 h / Ambient temperature
View Scheme
参考文献
Corsaro, Antonino; Buemi, Giuseppe; Chiacchio, Ugo; Perrini, Giancarlo; Pistara, Venerando; Romeo, Roberto
Tetrahedron, 1996 , vol. 52, # 23 p. 7885 - 7892
参考文献
Nagahara; Takagi; Ueda
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 12 p. 3178 - 3183
反应条件
hydrogenchloride in ethanol
参考文献
Nagahara,K.; Takada,A.
Heterocycles, 1979 , vol. 12, p. 239 - 242
反应条件
hydrogenchloride in ethanol
参考文献
Nagahara,K.; Takada,A.
Heterocycles, 1979 , vol. 12, p. 239 - 242
反应条件
1: 150 °C
2: Fe / acetic acid
View Scheme
参考文献
Nagahara; Takagi; Ueda
Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 12 p. 3178 - 3183
反应条件
sodium ethanolate in ethanol
Condensation; 10 h; Heating;
参考文献
Hansen, John Bondo; Christensen, Birgitte; Weiss, Jan; Suzdak, Peter D.; Sheardown, Malcolm J.; et al.
Medicinal Chemistry Research, 1995 , vol. 5, # 4 p. 308 - 315
反应条件
1: hydroxylamine / ethanol / 8 h / Reflux; Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Reflux
View Scheme
参考文献
Draghici, Bogdan; El-Gendy, Bahaa El-Dien M.; Katritzky, Alan R.
Synthesis, 2012 , vol. 44, # 4 p. 547 - 550
反应条件
in tetrahydrofuran
48 h; Ambient temperature;
参考文献
Corsaro, Antonino; Chiacchio, Ugo; Caramella, Pierluigi; Purrello, Giovanni
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 949 - 952