(6-氯-4-碘-3-吡啶)-氨基甲酸-1,1-二甲基乙酯合成路线 （共 6 条）
反应条件
1: With hydrogenchloride; water T=60°C; 12 h; 2: With sodium hydrogencarbonate in water T=20°C; pH=8; Saturated solution;
参考文献
US2009/253736 A1, ;
Page/Page column 29 ;
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine; iodine in diethyl ether
T=-78 - -10°C; 18 h;
参考文献
Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
反应条件
N,N,N',N,-tetramethylethylenediamine; iodine
参考文献
Dinnell, Kevin; Elliott, Jason Matthew; Hollingworth, Gregory John; Shaw, Duncan Edward
Patent: US2002/22624 A1, 2002 ;
反应条件
1: 94 percent / dioxane / 18 h / Heating
2: 55 percent / BuLi; I2; TMEDA / diethyl ether / 18 h / -78 - -10 °C
View Scheme
参考文献
Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
反应条件
1: 94 percent / dioxane / 18 h / Heating
2: 55 percent / BuLi; I2; TMEDA / diethyl ether / 18 h / -78 - -10 °C
View Scheme
参考文献
Cooper, Laura C.; Chicchi, Gary G.; Dinnell, Kevin; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Locker, Karen L.; Morrison, Denise; Shaw, Duncan E.; Tsao, Kwei-Lan; Watt, Alan P.; Williams, Angela R.; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1233 - 1236
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / |Inert atmosphere
1.2: 3 h / 0 °C
2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C
View Scheme
参考文献
Helsinn Healthcare SA; Fadini, Luca; Manini, Peter; Pietra, Claudio; Giuliano, Claudio; Lovati, Emanuela; Cannella, Roberta; Venturini, Alessio; Stella, Valentino J.
Patent: US8426450 B1, 2013 ;
