4-(2-氧代吲哚啉-1-基)哌啶-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
in diethyl ether; dichloromethane; trifluoroacetic acid
参考文献
Butler, Christopher R.; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sehon, Clark A.; Sun, Siquan; Tays, Kevin L.; Thurmond, Robin L.; Wei, Jianmei
Patent: US2005/101587 A9, 2005 ;
反应条件
1: in dichloromethane
T=20°C; 1 h;
2: With sodium tris(acetoxy)borohydride in dichloromethane
T=20°C; 24 h;
参考文献
Yang, Shyh-Ming; Tang, Yuting; Zhang, Rui; Lu, Huajun; Kuo, Gee-Hong; Gaul, Michael D.; Li, Yaxin; Ho, George; Conway, James G.; Liang, Yin; Lenhard, James M.; Demarest, Keith T.; Murray, William V.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6773 - 6776
反应条件
sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid in dichloromethane
参考文献
Butler, Christopher R.; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sehon, Clark A.; Sun, Siquan; Tays, Kevin L.; Thurmond, Robin L.; Wei, Jianmei
Patent: US2005/101587 A9, 2005 ;
反应条件
1: With p-ethylbenzene sulfonic acid in toluene
T=140°C; Inert atmosphere;
2: With di-tert-butyl dicarbonate; triethylamine in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Sumiyoshi, Takaaki; Enomoto, Takeshi; Takai, Kentaro; Takahashi, Yoko; Konishi, Yasuko; Uruno, Yoshiharu; Tojo, Kengo; Suwa, Atsushi; Matsuda, Harumi; Nakako, Tomokazu; Sakai, Mutsuko; Kitamura, Atsushi; Uematsu, Yasuaki; Kiyoshi, Akihiko
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 244 - 248
反应条件
1.1: sodium tris(acetoxy)borohydride; titanium (IV) isopropoxide; acetic acid / dichloromethane / |Inert atmosphere; |Reflux
2.1: p-ethylbenzene sulfonic acid / toluene / 140 °C / |Inert atmosphere
2.2: 0 °C / |Inert atmosphere
View Scheme
参考文献
Sumiyoshi, Takaaki; Enomoto, Takeshi; Takai, Kentaro; Takahashi, Yoko; Konishi, Yasuko; Uruno, Yoshiharu; Tojo, Kengo; Suwa, Atsushi; Matsuda, Harumi; Nakako, Tomokazu; Sakai, Mutsuko; Kitamura, Atsushi; Uematsu, Yasuaki; Kiyoshi, Akihiko
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 244 - 248
