4-溴-3,5-二甲基苯甲醛合成路线 （共 4 条）
反应条件
1: 2,5-dibromo-1,3-dimethylbenzene With n-butyllithium in diethyl ether; hexane T=-78°C; 0.75 h; 2: N,N-dimethyl-formamide in diethyl ether; hexane T=-78 - 20°C; Further stages.;
参考文献
Beinhoff, Matthias; Weigel, Wilfried; Jurczok, Martin; Rettig, Wolfgang; Modrakowski, Claudia; Bruedgam, Irene; Hartl, Hans; Schlueter, A. Dieter
European Journal of Organic Chemistry, 2001 , # 20 p. 3819 - 3829
反应条件
hydrogenchloride; n-butyllithium in diethyl ether; hexane; N,N-dimethyl-formamide
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
反应条件
pyridine; hydroxylamine hydrochloride in toluene 2 h; Heating;
参考文献
European Journal of Organic Chemistry, , # 20 p. 3819 - 3829
反应条件
1: 56 percent / hydroxylamine hydrochloride; pyridine / toluene / 2 h / Heating 2: 75 percent / CS2; aq. NaOH; (nBu)4NHSO4 / toluene / 20 h / 20 °C View Scheme
参考文献
Beinhoff, Matthias; Weigel, Wilfried; Jurczok, Martin; Rettig, Wolfgang; Modrakowski, Claudia; Bruedgam, Irene; Hartl, Hans; Schlueter, A. Dieter
European Journal of Organic Chemistry, 2001 , # 20 p. 3819 - 3829
