3-羟基-5-羰基-1-环戊烯-1-庚酸甲酯合成路线 （共 61 条）
反应条件
1: lipase (PPL) 2: quanidine / methanol / 0 °C 3: 84 percent / imidazole; Et3N / dimethylformamide View Scheme
参考文献
Rodriguez, Ana R.; Spur, Bernd W.
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4575 - 4579
反应条件
216 h; Ambient temperatureporcine pancreatic lipase;
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
反应条件
1: 46 percent / PPL 2: 98 percent / guanidine View Scheme
参考文献
Rodriguez, Ana R.; Spur, Bernd W.
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4575 - 4579
反应条件
triethylamine in chloroform
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: EP247620 A2, 1987 ;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: EP247620 A2, 1987 ;
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride
参考文献
Collins,P.W. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, # 9 p. 1152 - 1159
反应条件
silver perchlorate in water; acetone
1 h;
参考文献
Naora, Hirokazu; Ohnuki, Takashi; Nakamura, Asao
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 7 p. 2401 - 2404
反应条件
hydrogenchloride in methanol; toluene; benzene
参考文献
G. D. Searle and Co.
Patent: US3969391 A1, 1976 ;
反应条件
N-bromosuccinmide; silver perchlorate in tetrachloromethane; ethyl acetate
参考文献
Syntex (U.S.A.) Inc.
Patent: US4046801 A1, 1977 ;
反应条件
water; acetic acid in tetrahydrofuran
24 h; Ambient temperature;
参考文献
Gill, Melvyn; Rickards, Rodney W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 599 - 606
