3-羟基-5-羰基-1-环戊烯-1-庚酸甲酯合成路线 （共 61 条）
反应条件
silver(I) acetate; acetic acid; zinc in methanol
2 h; Heating;
参考文献
Naora, Hirokazu; Ohnuki, Takashi; Nakamura, Asao
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 7 p. 2401 - 2404
反应条件
1: aq. phosphate buffer; dioxane / 30 h / pH 8 / Heating
View Scheme
参考文献
Murcia, M. Carmen; De La Herran, Gabriela; Plumet, Joaquin; Csaky, Aurelio G.
Synlett, 2007 , # 10 p. 1553 - 1556
反应条件
1: aq. phosphate buffer; dioxane / 30 h / pH 8 / Heating
View Scheme
参考文献
Murcia, M. Carmen; De La Herran, Gabriela; Plumet, Joaquin; Csaky, Aurelio G.
Synlett, 2007 , # 10 p. 1553 - 1556
反应条件
chloral; triethylamine in toluene
Isomerization;
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
反应条件
1: aq. phosphate buffer; dioxane / 30 h / pH 8 / Heating
View Scheme
参考文献
Murcia, M. Carmen; De La Herran, Gabriela; Plumet, Joaquin; Csaky, Aurelio G.
Synlett, 2007 , # 10 p. 1553 - 1556
反应条件
1: 43 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 2.5 h / Heating
2: 92 percent / silver perchlorate / H2O; acetone / 1 h
View Scheme
参考文献
Naora, Hirokazu; Ohnuki, Takashi; Nakamura, Asao
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 7 p. 2401 - 2404
反应条件
hydrogenchloride
20 h; Ambient temperature;
参考文献
Gailite, V. A.; Freimanis, Ya. F.; Turovskii, I. V.; Gavars, M. P.; Ozola, A. Ya.; Dipan, I. V.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 7.1 p. 1267 - 1275
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 7 p. 1407 - 1417
反应条件
1: Me3SiCl / methanol / 24 h / 20 °C
2: 85 percent / porcine pancreatic lipase; NaOH / H2O / Enzymatic reaction; pH 7
3: Et3N / CCl4 / 0 °C
4: BF3*Et2O / CCl4 / 12 h
5: 95 percent / NaBH4 / methanol / 0 °C
6: hydroquinone; ZnCl2; water / dioxane / 6 h / Heating
View Scheme
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
反应条件
1: 85 percent / porcine pancreatic lipase; NaOH / H2O / Enzymatic reaction; pH 7
2: Et3N / CCl4 / 0 °C
3: BF3*Et2O / CCl4 / 12 h
4: 95 percent / NaBH4 / methanol / 0 °C
5: hydroquinone; ZnCl2; water / dioxane / 6 h / Heating
View Scheme
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
反应条件
1: 80 percent / p-TsOH, Et3O / dimethylformamide / Heating
2: 1.) aluminium trichloride; 2.) chlorotrimethylsilane / 1.) 1,2-dichloroethane, room temp., 1.5 h; 2.) 1,2-dichloroethane, room temp., 24 h, 80 deg C 28 h
3: triphenylphosphine, bromine, triethylamine / 1.) benzene, room temp., 17 h; 2.) benzene, 15 min
4: 96 percent / silver acetate, glacialacetic acid, zinc powder (activated by HCl) / methanol / 24 h / 60 °C
5: 43 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 2.5 h / Heating
6: 92 percent / silver perchlorate / H2O; acetone / 1 h
View Scheme
参考文献
Naora, Hirokazu; Ohnuki, Takashi; Nakamura, Asao
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 7 p. 2401 - 2404
