乙基5-氧代-1-环戊烯-1-羧酸酯合成路线 （共 31 条）
反应条件
1: 56 percent
2: p-toluenesulfonic acid / Heating
3: 1) CaCO3, Br2, 2) Li2CO3, / 1) CCl4, water, 0-5 deg C, 30 min, 2) DMF, 30 min, reflux
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: p-toluenesulfonic acid / Heating
2: 1) CaCO3, Br2, 2) Li2CO3, / 1) CCl4, water, 0-5 deg C, 30 min, 2) DMF, 30 min, reflux
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 56 percent
2: p-toluenesulfonic acid / Heating
3: 1) CaCO3, Br2, 2) Li2CO3, / 1) CCl4, water, 0-5 deg C, 30 min, 2) DMF, 30 min, reflux
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
bromine; lithium carbonate; calcium carbonate
1) CCl4, water, 0-5 deg C, 30 min, 2) DMF, 30 min, reflux; Yield given. Yields of byproduct given;
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
bromine; lithium carbonate; calcium carbonate; lithium bromide
1) CCl4, water, 30 min, CCl4, 2) DMF, 30 min, reflux; Yield given. Yields of byproduct given;
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
N-bromosuccinmide
1.) CCl4, reflux, 2 h; 2.) DMFA, ethanol, reflux, 2 h; Yield given. Multistep reaction;
参考文献
Bokaldere, R. P.; Liepinya, A. Ya.; Lozha, E. V.; Lolya, D. O.; Freimanis, Ya. F.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 11 p. 2119 - 2123
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 11 p. 2371 - 2376
反应条件
1: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
2: 2N HCl / acetone / 5 h / Heating
3: 80.6 percent / p-toluenesulfonic acid / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
1: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
2: 84.6 percent / 25percent (i-Bu)2AlH / benzene; hexane / 1.5 h / 0 - 5 °C
3: 77.9 percent / triethylamine / CH2Cl2 / 0.5 h
4: 57percent NaH / 1,2-dimethoxy-ethane / 18 h / Heating
5: 64.2 percent / KOH / H2O; methanol / 18 h / Heating
6: 84 percent / various solvent(s) / Heating
7: 90 percent / 2N HCl / acetone / 5 h / Heating
8: 94.9 percent / p-toluenesulfonic acid / 17 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
反应条件
(i) NBS, (irradiation), (ii) AgOAc; Multistep reaction;
参考文献
Bernady; Floyd; Poletto; Weiss
Journal of Organic Chemistry, 1979 , vol. 44, # 9 p. 1438 - 1446
反应条件
1: 95.8 percent / pyridine; ethanol / 22 h / Ambient temperature
2: 2N HCl / acetone / 5 h / Heating
View Scheme
参考文献
Bernady; Poletto; Nocera; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715
