3,5-双三氟甲基苯甲醛合成路线 （共 36 条）
反应条件
in tetrahydrofuran T=-70 - 20°C;
参考文献
CLARIANT GMBH
Patent: WO2004/24663 A1, 2004 ;
Location in patent: Page/Page column 12-13 ;
反应条件
(i) Mg, (ii) /BRN= 605384/; Multistep reaction;
参考文献
Eriks Ch.; Van Der Goot; Nauta Th.
European Journal of Medicinal Chemistry, 1979 , vol. 14, # 5 p. 411 - 414
反应条件
ammonium acetate; acetic acid T=100°C; 12 h;
参考文献
Williams, Darren R.; Ko, Sung-Kyun; Park, Sungjin; Lee, Myung-Ryul; Shin, Injae
Angewandte Chemie - International Edition, 2008 , vol. 47, # 39 p. 7466 - 7469
反应条件
1: trimethyl-oxo-sulfonium iodide With sodium hydride in dimethyl sulfoxide 0.0833333 h; 2: 3,5-bis-(trifluoromethyl)-benzaldehyde in dimethyl sulfoxide T=20°C; 1 h;
参考文献
Thompson, Christopher F.; Ali, Amjad; Quraishi, Nazia; Lu, Zhijian; Hammond, Milton L.; Sinclair, Peter J.; Anderson, Matt S.; Eveland, Suzanne S.; Guo, Qiu; Hyland, Sheryl A.; Milot, Denise P.; Sparrow, Carl P.; Wright, Samuel D.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 6 p. 424 - 427
反应条件
hydrogen; nickel in toluene T=50°C; P=22502.3 Torr; 7.5 h;
参考文献
Baumann, Kathe; Marhold, Albrecht
Patent: US2002/38055 A1, 2002 ;
反应条件
(S)-12-(hydroxymethyl)-14-methyl-1(5,8)-quinolina-4(1,4)-benzenacyclohexaphane in toluene T=20°C; 3 h; Title compound not separated from byproducts;
参考文献
Ruzziconi, Renzo; Piermatti, Oriana; Ricci, Giacomo; Vinci, Daniele
Synlett, 2002 , # 5 p. 747 - 750
反应条件
1.1: titanium(IV) isopropylate / dichloromethane / 20 h / 0 - 20 °C / |Inert atmosphere 2.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / |Inert atmosphere 3.2: 3 h / -60 - 20 °C 4.1: hydrogenchloride / methanol / 0.25 h / |Inert atmosphere View Scheme
参考文献
LEO PHARMA A/S; SØRENSEN, Morten, Dahl; DI FABIO, Romani; POZZAN, Alfonso; CATALANI, Maria, Pia; BLADH, Haakon; FELDING, Jakob
Patent: WO2013/124286 A1, 2013 ;
反应条件
1: in tetrahydrofuran T=0°C; 0.5 h; 2: With hydrogenchloride; water in tetrahydrofuran pH=< 7;
参考文献
KOWA COMPANY, LTD.
Patent: US2009/82352 A1, 2009 ;
Location in patent: Page/Page column 29 ;
US 20090082352 A1
参考文献
Bloom, Jonathan D.; Dushin, Russell G.; Curran, Kevin J.; Donahue, Fran; Norton, Emily B.; Terefenko, Eugene; Jones, Thomas R.; Ross, Adma A.; Feld, Boris; Lang, Stanley A.; DiGrandi, Martin J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 13 p. 3401 - 3406
反应条件
sodium hydride Horner-Wadsworth-Emmons Olefination;
参考文献
Galano, Juan J.; Alias, Miriam; Perez, Reyes; Velazquez-Campoy, Adrian; Hoffman, Paul S.; Sancho, Javier
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6248 - 6258
