1.1: NaH / dimethylformamide / 0.5 h / 90 °C 1.2: 100 percent / dimethylformamide / 1 h / 100 °C 2.1: 96 percent / α-chloroethyl chloroformate / 1,2-dichloro-ethane / 1.33 h / 0 - 50 °C View Scheme

1: (R)-(+)-3-(dimethylamino)-1-phenylpropan-1-ol With methanesulfonyl chloride; triethylamine in acetonitrile T=20°C; 3 h; 2: 4-(trifluoromethyl)phenol With potassium carbonate in acetonitrile 65 h; Heating;