5,6-二氢-4H-环戊基(b)噻吩-2-羧酸合成路线 （共 3 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran; ethanol; water T=50°C; 3 h;
参考文献
NIMBUS IRIS, INC.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert
Patent: WO2014/11906 A2, 2014 ;
Location in patent: Paragraph 00260 ;
反应条件
1: trichlorophosphate / toluene / 2 h / 0 - 20 °C / |Inert atmosphere 2: triethylamine / pyridine / 1 h / 0 - 20 °C 3: lithium hydroxide hydrate / tetrahydrofuran; ethanol; water / 3 h / 50 °C View Scheme
参考文献
NIMBUS IRIS, INC.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert
Patent: WO2014/11906 A2, 2014 ;
反应条件
1: triethylamine / pyridine / 1 h / 0 - 20 °C 2: lithium hydroxide hydrate / tetrahydrofuran; ethanol; water / 3 h / 50 °C View Scheme
参考文献
NIMBUS IRIS, INC.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert
Patent: WO2014/11906 A2, 2014 ;
