5-(4-溴苯基)噻吩-2-羧酸合成路线 （共 9 条）
反应条件
sodium hydroxide; silver(l) oxide in water
T=20 - 50°C;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
2: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: AlCl3 / CS2 / 2.5 h / 20 °C
2.1: dimethylformamide / 22 h / 5 °C
3.1: H2SO4 / methanol / 1 h / Heating
3.2: chloranil / benzene / 2 h / Heating
4.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
5.1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: dimethylformamide / 22 h / 5 °C
2.1: H2SO4 / methanol / 1 h / Heating
2.2: chloranil / benzene / 2 h / Heating
3.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
4.1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: H2SO4 / methanol / 1 h / Heating
1.2: chloranil / benzene / 2 h / Heating
2.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating
3.1: 76 percent / NaOH; Ag2O / H2O / 20 - 50 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
sulfuric acid in toluene
7 h; Heating;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 83 percent / H2SO4 / toluene / 7 h / Heating
2: LiAlH4 / diethyl ether / Heating
3: HMPA; thionyl chloride / tetrahydrofuran / 20 °C
4: 18-crown-6 / acetonitrile / 20 °C
5: KOH / ethanol; H2O / Heating
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 83 percent / H2SO4 / toluene / 7 h / Heating
2: LiAlH4 / diethyl ether / Heating
3: HMPA; thionyl chloride / tetrahydrofuran / 20 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 83 percent / H2SO4 / toluene / 7 h / Heating
2: LiAlH4 / diethyl ether / Heating
3: HMPA; thionyl chloride / tetrahydrofuran / 20 °C
4: 18-crown-6 / acetonitrile / 20 °C
View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
