5-(4-氯苯在)噻吩-2-羧酸合成路线 （共 17 条）
反应条件
1: With sodium hydroxide; water in methanol 6 h; Heating / reflux; 2: With hydrogenchloride in methanol; water T=20°C; pH=3;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/269110 A1, 2008 ;
Location in patent: Page/Page column 18 ;
US 20080269110 A1
反应条件
ethylaluminum dichloride in hexane; toluene T=100°C; P=22502.3 Torr; 3 h; AutoclaveInert atmosphere; regioselective reaction;
参考文献
Nemoto, Koji; Onozawa, Satoru; Konno, Megumi; Morohashi, Naoya; Hattori, Tetsutaro
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 3 p. 369 - 371
反应条件
sodium hydroxide; silver(l) oxide in water T=20 - 50°C;
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
iodine in 1,4-dioxane T=80°C; 24 h;
参考文献
Campaigne, E.; White, R.L.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 367 - 373
反应条件
1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating 2: 86 percent / NaOH; Ag2O / H2O / 20 - 50 °C View Scheme
参考文献
Buu-Hoi; Hoan
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 1455,1466
反应条件
1.1: AlCl3 / CS2 / 2.5 h / 20 °C 2.1: dimethylformamide / 22 h / 5 °C 3.1: H2SO4 / methanol / 1 h / Heating 3.2: chloranil / benzene / 2 h / Heating 4.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating 5.1: 86 percent / NaOH; Ag2O / H2O / 20 - 50 °C View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: dimethylformamide / 22 h / 5 °C 2.1: H2SO4 / methanol / 1 h / Heating 2.2: chloranil / benzene / 2 h / Heating 3.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating 4.1: 86 percent / NaOH; Ag2O / H2O / 20 - 50 °C View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1.1: H2SO4 / methanol / 1 h / Heating 1.2: chloranil / benzene / 2 h / Heating 2.1: POCl3 / 1,2-dichloro-ethane / 17 h / Heating 3.1: 86 percent / NaOH; Ag2O / H2O / 20 - 50 °C View Scheme
参考文献
Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742
反应条件
1: 65 percent / sodium acetate / acetic acid / 0.5 h / Heating 2: 71 percent / 5percent NaOH / 0.5 h / 80 °C 3: 30percent H2O2 / pyridine / 5 h 4: 80 percent / iodine / dioxane / 24 h / 80 °C View Scheme
参考文献
Campaigne, E.; White, R.L.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 367 - 373
反应条件
1: 30percent H2O2 / pyridine / 5 h 2: 80 percent / iodine / dioxane / 24 h / 80 °C View Scheme
参考文献
Campaigne, E.; White, R.L.
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 367 - 373
