(9ci)-2-氯-5-氟-1-甲基-1H-苯并咪唑合成路线 （共 5 条）
反应条件
trichlorophosphate
2 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2010/305102 A1, 2010 ;
Location in patent: Page/Page column 28 ;
US 20100305102 A1
反应条件
1: 1,1'-carbonyldiimidazole / tetrahydrofuran
2: N,N-diethylaniline / trichlorophosphate; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28932 A1, 2012 ;
反应条件
2: ethyl acetate
3: 1,1'-carbonyldiimidazole / tetrahydrofuran
4: N,N-diethylaniline / trichlorophosphate; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28932 A1, 2012 ;
反应条件
1: ethyl acetate
2: 1,1'-carbonyldiimidazole / tetrahydrofuran
3: N,N-diethylaniline / trichlorophosphate; (2S)-N-methyl-1-phenylpropan-2-amine hydrate
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28932 A1, 2012 ;
反应条件
1: hydrogen / ethyl acetate / 4.5 h / 20 °C / 3750.38 Torr
2: tetrahydrofuran / 48 h / 20 °C
3: trichlorophosphate / 2 h / |Reflux
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Nickolaus, Peter
Patent: US2013/237527 A1, 2013 ;
