反应条件
<b>Multi-step reaction with 12 steps<br /> </b>1: TFA / CH<sub>2</sub>Cl<sub>2</sub> / 0.58 h / 0 °C<br />2: 454 mg / DEBPT; i-Pr<sub>2</sub>NEt<sub>2</sub> / tetrahydrofuran / 18 h / 20 °C<br />3: 2,6-lutidine / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 20 °C<br />4: 143 mg / aq. LiOH / 2-methyl-propan-2-ol / 16 h / 20 °C<br />5: 78 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide; CH<sub>2</sub>Cl<sub>2</sub> / 24 h / 0 - 20 °C<br />6: 88 percent / β-bromocatecholborane / CH<sub>2</sub>Cl<sub>2</sub> / 0.5 h / -78 °C<br />7: H<sub>2</sub>; 2,2'-bipyridyl / Pd/C / methanol; ethyl acetate / 2 h<br />8: 37.7 mg / 2,4,6-collidine / CH<sub>2</sub>Cl<sub>2</sub> / 3 h / 20 °C<br />9: Dess-Martin periodinane / CH<sub>2</sub>Cl<sub>2</sub> / 1.25 h / 0 - 25 °C<br />10: aq. NaClO<sub>2</sub>; NaH<sub>2</sub>PO<sub>4</sub>*2H<sub>2</sub>O / 2-methyl-propan-2-ol; various solvent(s) / 0.33 h / 25 °C<br />11: 28.4 mg / 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; i-Pr<sub>2</sub>NEt<sub>2</sub> / tetrahydrofuran / 18 h / 20 °C<br />12: 77 percent / MTBD / dimethylformamide / 1.5 h / 20 °C<br /> <br />
参考文献
Cao, Bin; Park, Haengsoon; Joullie, Madeleine M. Journal of the American Chemical Society, 2002 , vol. 124, # 4 p. 520 - 521
