potassium tert-butylate; oxygen; triethyl phosphite in N,N-dimethyl-formamide; tert-butyl alcohol T=-25°C; 2 h;

1: H2, Et3N / Pd-C / ethanol 2: O2, KOtBu, (EtO)3P / 2-methyl-propan-2-ol; dimethylformamide / 2 h / -25 °C View Scheme

1: aq. H2SO4 / 1,2-dimethoxy-ethane 2: H2, Et3N / Pd-C / ethanol 3: O2, KOtBu, (EtO)3P / 2-methyl-propan-2-ol; dimethylformamide / 2 h / -25 °C View Scheme