1-甲基-1,2,3,6-四氢吡啶-4-羧酸乙酯合成路线 （共 5 条）
反应条件
1: in ethyl acetate T=80°C; 3 h; 2: With sodium tetrahydroborate in ethanol T=-40 - 20°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2009/156572 A1, 2009 ;
Location in patent: Page/Page column 37 ;
US 20090156572 A1
反应条件
sodium tetrahydroborate; ethanol unter Kuehlung;
参考文献
Proctor, George R.; Smith, Francis J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1754 - 1762
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2250.2 - 3000.2 Torr; 24 h;
参考文献
McKnight, William E.; Proctor, George R.; Sneddon, Andrew H.; Scopes, David I. C.
Journal of Chemical Research, Miniprint, 1987 , # 3 p. 642 - 679
反应条件
1: in diethyl ether T=0°C; 2 h; 2: With water; ammonium chloride in diethyl ether
参考文献
Kinney, William A.; Luci, Diane K.; Maryanoff, Bruce E.
Patent: US2005/26917 A1, 2005 ;
Location in patent: Page/Page column 15-16 ;
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Ferles
Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 2221,2228
Chemicke Listy, 1958 , vol. 52, p. 674
