5-甲基-2-吡啶羧酸甲酯 N-氧化物合成路线 （共 6 条）
反应条件
1: With trichlorophosphate in chloroform T=80°C; 0.0833333 h; 2: With potassium carbonate in chloroform; water pH=7;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/10794 A1, 2009 ;
Location in patent: Page/Page column 62-63 ;
WO 2009/010794 A1
反应条件
3-chloro-benzenecarboperoxoic acid in chloroform
T=20°C; 15 h;
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E.
Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2385 - 2387
反应条件
1: SeO2 / pyridine / 26 h / Heating
2: 8.2 g / conc. H2SO4 / 8 h / Heating
3: 78 percent / m-CPBA / CHCl3 / 15 h / 20 °C
View Scheme
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E
Tetrahedron, 2002 , vol. 58, # 34 p. 6951 - 6963
反应条件
1: 8.2 g / conc. H2SO4 / 8 h / Heating
2: 78 percent / m-CPBA / CHCl3 / 15 h / 20 °C
View Scheme
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E
Tetrahedron, 2002 , vol. 58, # 34 p. 6951 - 6963
反应条件
1.1: Ac2O / 3 h / Heating
1.2: 51 percent / NaOMe / methanol / 0.17 h / 0 °C
2.1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C
3.1: 77 percent / AIBN; NBS / CCl4 / Heating
4.1: 34 percent / hexamethylenetetramine; aq. acetic acid / 1 h / Heating
View Scheme
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E.
Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2385 - 2387
反应条件
1.1: Ac2O / 3 h / Heating
1.2: 51 percent / NaOMe / methanol / 0.17 h / 0 °C
2.1: 93 percent / Ag2CO3 / CHCl3 / 120 h / 20 °C
3.1: 77 percent / AIBN; NBS / CCl4 / Heating
View Scheme
参考文献
Adamczyk, Maciej; Akireddy, Srinivasa Rao; Reddy, Rajarathnam E.
Tetrahedron Asymmetry, 2001 , vol. 12, # 17 p. 2385 - 2387
