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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
401813-34-1
合成路线
（共 9 条）
50-00-0
甲醛
+
43036-17-5
4-(6-甲氧基-1,3-苯并噻唑-2-基)苯胺
→
反应条件
401813-34-1
反应条件
1: With sodium methylate in methanol T=20°C; 4 h; 2: With sodium tetrahydroborate 1.5 h; Reflux;
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
Location in patent: Page/Page column 14 ;
10541-83-0
4-(甲基氨基)苯甲酸
+
6274-29-9
2-氨基-5-甲氧基苯硫酚
→
反应条件
401813-34-1
反应条件
PPA T=170°C; 1.5 h;
参考文献
UNIVERSITY OF PITTSBURGH
Patent: WO2006/14382 A1, 2006 ;
Location in patent: Page/Page column 47 ;
2942-13-4
6-甲氧基苯并噻唑
+
6911-87-1
4-溴-N-甲基苯胺
→
反应条件
401813-34-1
反应条件
caesium carbonate; copper(I) bromide; Pd(OAc)2*P(t-Bu)3 in N,N-dimethyl-formamide T=150°C; 3 h;
参考文献
Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D.
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1349 - 1351
43036-17-5
4-(6-甲氧基-1,3-苯并噻唑-2-基)苯胺
+
74-88-4
甲基碘
→
反应条件
10205-71-7
4-(6-甲氧基苯并[d]噻唑-2-基)-N,N-二甲基苯胺
+
401813-34-1
反应条件
potassium carbonate in dimethyl sulfoxide T=100°C; 16 h;
参考文献
UNIVERSITY OF PITTSBURGH
Patent: US2003/236391 A1, 2003 ;
Location in patent: Page 15 - 16 ;
1747-60-0
2-氨基-6-甲氧基苯并噻唑
→
反应条件
401813-34-1
反应条件
1: 15.3 g / aq. KOH / ethane-1,2-diol / 48 h / Heating 2: 21 percent / polyphosphoric acid / 1.5 h / 170 °C View Scheme
参考文献
Mathis, Chester A; Wang, Yanming; Holt, Daniel P; Huang, Guo-Feng; Debnath, Manik L; Klunk, William E
Journal of medicinal chemistry, 2003 , vol. 46, # 13 p. 2740 - 2754
24730-11-8
→
反应条件
401813-34-1
反应条件
1.1: Lawesson's reagent / chlorobenzene / 6 h / Reflux 2.1: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C 3.1: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere 4.1: sodium methylate / methanol / 4 h / 20 °C 4.2: 1.5 h / Reflux View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
104-94-9
对甲氧基苯胺
→
反应条件
401813-34-1
反应条件
1.1: pyridine / 2 h / 100 °C 2.1: Lawesson's reagent / chlorobenzene / 6 h / Reflux 3.1: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C 4.1: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere 5.1: sodium methylate / methanol / 4 h / 20 °C 5.2: 1.5 h / Reflux View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
122-04-3
氯化对硝基苯甲酰
→
反应条件
401813-34-1
反应条件
1.1: pyridine / 2 h / 100 °C 2.1: Lawesson's reagent / chlorobenzene / 6 h / Reflux 3.1: sodium hydroxide; K3Fe(CN)6 / ethanol; water / 1 h / 90 °C 4.1: tin(ll) chloride / ethanol / 4 h / Reflux; Inert atmosphere 5.1: sodium methylate / methanol / 4 h / 20 °C 5.2: 1.5 h / Reflux View Scheme
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
401813-34-1
→
反应条件
566169-93-5
2-[4-(甲基氨基)苯基]-1,3-苯并噻唑-6-醇
反应条件
boron tribromide in dichloromethane; water T=20°C; 12 h;
参考文献
Chi, Dae-Yoon; Lee, Byoung-Se; Uthaiwan, Sirion; Chu, So-Young; Bae, Yu-Jin; Park, Chansoo; Moon, Dae-Hyuk; Ryu, Jin-Sook; Kim, Jae-Seung; Oh, Seung-Jun
Patent: US2012/214994 A1, 2012 ;
Location in patent: Page/Page column 14 ;
