2-(苄基硫代)-4-氯苯甲酸合成路线 （共 4 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene 3 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 20 p. 4044 - 4057
反应条件
1: SOCl2, DMF / toluene / 3 h / Heating 2: 1.) Cl2 (gas), 2.) aq. NH4OH / 1.) CCl4, 1 h 3: 3.8 g / PCl5, POCl3 / 2 h / 120 °C 4: 2.0 g / chlorobenzene / 18 h / Heating View Scheme
参考文献
Hrib, Nicholas J.; Jurcak, John G.; Bregna, Deborah E.; Burgher, Kendra L.; Hartman, Harold B.; Kafka, Sharon; Kerman, Lisa L.; Kongsamut, Sam; Roehr, Joachim E.; Szewczak, Mark R.; Woods-Kettelberger, Ann T.; Corbett, Roy
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 4044 - 4057
反应条件
potassium carbonate; copper(l) chloride in N,N-dimethyl-formamide
T=120°C; 18 h;
参考文献
Hrib, Nicholas J.; Jurcak, John G.; Bregna, Deborah E.; Burgher, Kendra L.; Hartman, Harold B.; Kafka, Sharon; Kerman, Lisa L.; Kongsamut, Sam; Roehr, Joachim E.; Szewczak, Mark R.; Woods-Kettelberger, Ann T.; Corbett, Roy
Journal of Medicinal Chemistry, 1996 , vol. 39, # 20 p. 4044 - 4057
反应条件
sodium hydroxide in ethanol
Heating;
参考文献
Clarke,K. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 356 - 359
