2-氨基-4-三氟甲基苯甲酸合成路线 （共 24 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=5250.53 Torr; 2 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/108591 A1, 2006 ;
Location in patent: Page/Page column 10; 66 ;
WO 2006/108591 A1
反应条件
sulfuric acid Heating;
参考文献
Sandoz, Inc.
Patent: US4307113 A1, 1981 ;
反应条件
1: aqueous H2SO4 / 165 °C 2: iron-powder; aqueous NH4Cl View Scheme
参考文献
Suez, Gal; Bloch, Victoria; Nisnevich, Gennady; Gandelman, Mark
European Journal of Organic Chemistry, 2012 , # 11 p. 2118 - 2122
反应条件
1: (i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3 2: H2 / Raney-Ni / methanol 3: aq. H2SO4 / Heating View Scheme
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
1: NH2OH*HCl, Na2SO4, conc. HCl / dioxane; H2O / 0.75 h / Heating 2: 1.) conc. H2SO4, 2.) 30percent aq. H2O2, 1 N aq. NaOH / 1.) 80 deg C, 10 min, 2.) RT View Scheme
参考文献
Rowley, Michael; Leeson, Paul D.; Stevenson, Graeme I.; Moseley, Angela M.; Stansfield, Ian; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3386 - 3396
反应条件
1: 67 percent / HNO3 (d=1.5) / 1 h / Heating 2: 2.05 g / H2 / Pd/A-Kohle / methanol View Scheme
参考文献
Giencke, Astrid; Lackner, Helmut
Liebigs Annalen der Chemie, 1990 , # 6 p. 569 - 579
反应条件
1: borane-THF / tetrahydrofuran / 1.5 °C / |Inert atmosphere 2: boron tribromide / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
hydrogenchloride 12 h; Heating;
参考文献
Hill; Stanley; Karoglan Williams; Loev; Fowler; McCafferty; Macko; Berkoff; Ladd
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 865 - 869
参考文献
Rowley, Michael; Leeson, Paul D.; Stevenson, Graeme I.; Moseley, Angela M.; Stansfield, Ian; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3386 - 3396
参考文献
Imperial Chemical Industries, PLC
Patent: US5599814 A1, 1997 ;
