3-氨基-4-硝基三氟甲苯合成路线 （共 19 条）
反应条件
1: SnCl2*H2O / ethyl acetate; ethanol / 0.58 h / 70 °C 2: aq. SeO2 / ethanol / 0.5 h / Heating 3: concd. H2SO4, concd. HNO3 / 1 h / 10 °C 4: concd. HCl, 48percent HI / 2 h / Ambient temperature View Scheme
参考文献
Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379
反应条件
N-bromosuccinmide in acetic acid 4 h; Reflux;
参考文献
Diaz, Caroline Jean; Haffner, Curt Dale; Speake, Jason Daniel; Zhang, Cunyu; Mills, Wendy Yoon; Spearing, Paul Kenneth; Cowan, David John; Green, Gary Martin
Patent: US2010/222345 A1, 2010 ;
Location in patent: Page/Page column 88 ;
反应条件
1: SnCl2; aq.-ethanolic HCl 2: aqueous HCl View Scheme
参考文献
Sykes; Tatlow
Journal of the Chemical Society, 1952 , p. 4078
反应条件
1: arsenic (V)-oxide; sulfuric acid 2: SnCl2; aqueous HCl 3: water; sulfuric acid; hypophosphoric acid / mit Natriumnitrit in Wasser View Scheme
参考文献
Belcher et al.
Journal of the Chemical Society, 1954 , p. 3846,3849
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) -10 deg C, 2.) from RT to 100 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Brune, Hans-Albert; Hohenadel, Robert; Schmidtberg, Guenther; Ziegler, Ulrich
Journal of Organometallic Chemistry, 1991 , vol. 402, # 2 p. 171 - 178
反应条件
(i) NaNO2, aq. H2SO4, (ii) aq. KI; Multistep reaction;
参考文献
Gronnier, Colombe; Boissonnat, Guillaume; Gagosz, Fabien
Organic Letters, 2013 , vol. 15, # 16 p. 4234 - 4237
反应条件
1.1: hydrogenchloride / water / 0.17 h / 100 °C 1.2: 0.5 h / 0 °C 1.3: 2 h / 0 - 70 °C 2.1: FeCl3·6H2O; carbon; hydrazine hydrate / methanol / 65 °C View Scheme
参考文献
Gronnier, Colombe; Boissonnat, Guillaume; Gagosz, Fabien
Organic Letters, 2013 , vol. 15, # 16 p. 4234 - 4237
反应条件
1: arsenic (V)-oxide; sulfuric acid
2: SnCl2; aqueous HCl
View Scheme
参考文献
Belcher et al.
Journal of the Chemical Society, 1954 , p. 3846,3849
反应条件
sulfuric acid
T=80°C; 1 h;
参考文献
Navarrete-Vazquez, Gabriel; Rojano-Vilchis, Maria De Monserrat; Yepez-Mulia, Lilian; Melendez, Victor; Gerena, Lucia; Hernandez-Campos, Alicia; Castillo, Rafael; Hernandez-Luis, Francisco
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 135 - 141
