反式-4-羟基-L-脯氨酸甲酯盐酸盐合成路线 (共 70 条)
反应条件
thionyl chloride 4 h; Ambient temperature;
参考文献
Westwood, Nigel B.; Walker, Richard T.
Tetrahedron, 1998 , vol. 54, # 44 p. 13391 - 13404
反应条件
thionyl chloride in methanol
参考文献
Shionogi Seiyaku Kabushiki Kaisha
Patent: US5317016 A1, 1994 ;
反应条件
hydrogenchloride T=20°C; 12 h;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad; NICHOLAS, John, B.; SEREBRYANY, Vladimir; SEIWERT, Scott, D.
Patent: WO2012/37259 A1, 2012 ;
Location in patent: Page/Page column 74 ;
WO 2012/037259 A1
反应条件
thionyl chloride T=0 - 20°C; Reflux;
参考文献
ONO PHARMACEUTICAL CO., LTD; IMAGAWA, Akira; KONDO, Takashi; NISHIYAMA, Taihei; COURTNEY, Steve; YARNOLD, Chris; ICHIHARA, Osamu; FLANAGAN, Stuart
Patent: WO2013/174937 A1, 2013 ;
Location in patent: Page/Page column 74 ;
反应条件
in methanol 8 h; Heating;
参考文献
Cho, Han-Won; Oh, Chang-Hyun; Lee, Ju-Shin; Lee, Soo-Chul; Choi, Jung-Hoon; Cho, Jung-Hyuck
Archiv der Pharmazie, 2003 , vol. 336, # 11 p. 495 - 503
反应条件
hydrogenchloride Ambient temperature;
参考文献
Papaioannou, Dionissios; Stavropoulos, George; Karagiannis, Kostas; Francis, George W.; Brekke, Trond; Aksnes, Dagfinn W.
Acta Chemica Scandinavica, 1990 , vol. 44, # 3 p. 243 - 251
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: lithium borohydride / tetrahydrofuran / 20 °C View Scheme
参考文献
ALNYLAM PHARMACEUTICALS, INC.; JAYAPRAKASH, Narayanannair, K.; KELIN, Alexander, V.; KANDASAMY, Pachamuthu; KALLANTHOTTATHIL, Rajeev, G.; MANOHARAN, Muthiah
Patent: WO2014/25805 A1, 2014 ;
反应条件
1: triethylamine / dichloromethane / 20 °C 2: triethylamine / dichloromethane / 1.83 h / 0 - 20 °C 3: dimethyl sulfoxide / 72 h / 55 °C / |Inert atmosphere View Scheme
反应条件
1: triethylamine / acetonitrile / 0 - 20 °C 2: triethylamine / dichloromethane / 20 h / 0 - 20 °C 3: dimethyl sulfoxide / 4 h / 80 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 36 p. 9539 - 9543
Angew. Chem., , vol. 125, # 36 p. 9718 - 9722
反应条件
1: sodium hydrogencarbonate / 1,4-dioxane; water / 24 h / 20 °C 2: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C / |Inert atmosphere 3: lithium hydroxide hydrate / 1,4-dioxane; water / 3 h / 20 °C 4: ammonium hydrogen carbonate; pyridine / 1,4-dioxane / 6 h / 20 °C 5: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 23 p. 7418 - 7429