反式-4-羟基-L-脯氨酸甲酯盐酸盐合成路线 （共 70 条）
反应条件
1: 76 percent / Et3N / CHCl3 / 0 °C 2: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 3: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 4: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 5: TFA / CH2Cl2 View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 76 percent / Et3N / CHCl3 / 0 °C 2: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 3: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 4: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 5: TFA / CH2Cl2 6: Et3N / methanol View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 76 percent / Et3N / CHCl3 / 0 °C 2: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 3: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 4: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature 5: TFA / CH2Cl2 View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 95 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 2: 93 percent / (COCl)2; Et3N; DMSO / CH2Cl2 / -78 °C 3: 90 percent / DAST / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 95 percent / Et3N / CH2Cl2 / 2 h / 0 - 20 °C 2: 85 percent / DAST / CH2Cl2 / -78 - 20 °C View Scheme
参考文献
Wang, Jiang; Feng, Ying; Ji, Xun; Deng, Guanghui; Leng, Ying; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 23 p. 7418 - 7429
反应条件
1: 95 percent / Et3N / CH2Cl2 / Ambient temperature 2: 81 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature 4: TFA / CH2Cl2 5: Et3N / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 95 percent / Et3N / CH2Cl2 / Ambient temperature 2: 81 percent / DAST / CH2Cl2 / -78 deg C to r.t. 3: 92 percent / LiOH / acetonitrile; H2O / Ambient temperature View Scheme
参考文献
Ji, Xun; Su, Mingbo; Wang, Jiang; Deng, Guanghui; Deng, Sisi; Li, Zeng; Tang, Chunlan; Li, Jingya; Li, Jia; Zhao, Linxiang; Jiang, Hualiang; Liu, Hong
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 111 - 122
反应条件
1: 95 percent / Et3N / CH2Cl2 / Ambient temperature 2: 81 percent / PDC, 3 Angstroem molecular sieves / CH2Cl2 / Ambient temperature 3: 89 percent / DAST / CH2Cl2 / -78 deg C to r.t. 4: 95 percent / LiOH / acetonitrile; H2O / Ambient temperature View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 76 percent / Et3N / CHCl3 / 0 °C 2: 1.) PPh3, DEAD, PhCO2H; 2.) KOH / 1.) toluene; 2.) MeOH 3: 63 percent / DAST / CH2Cl2 / -78 deg C to r.t. 4: 99 percent / LiOH / acetonitrile; H2O / Ambient temperature View Scheme
参考文献
Demange, Luc; Menez, Andre; Dugave, Christophe
Tetrahedron Letters, 1998 , vol. 39, # 10 p. 1169 - 1172
反应条件
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 3: 88.7 percent / dimethylsulfoxide / 90 °C 4: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 5: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 6: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C View Scheme
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
