1-[(三甲基硅基)乙炔基]-3-(三氟甲基)苯合成路线 （共 4 条）
反应条件
potassium carbonate in ethanol T=20°C; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/94822 A1, 2005 ;
Location in patent: Page/Page column 31 ;
WO 2005/094822 A1
反应条件
water; triethylamine; triphenylphosphine; [RhCl(η2:η2-cycloocta-1,5-diene)]2 in tetrahydrofuran T=160°C; P=51485.6 Torr; 4 h;
参考文献
Takeuchi, Ryo; Yasue, Hiroyuki
Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5386 - 5392
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in ethyl acetate
T=50°C; Sonogashira Coupling; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/94822 A1, 2005 ;
Location in patent: Page/Page column 30-31 ;
WO 2005/094822 A1
反应条件
copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; Sonogashira coupling;
参考文献
Gottardo, Christine; Aguirre, Andrea
Tetrahedron Letters, 2002 , vol. 43, # 39 p. 7091 - 7094
