1-[(三甲基硅基)乙炔基]-4-(三氟甲基)苯合成路线 (共 15 条)
反应条件
(alkaline hydrolysis);
参考文献
Tetrahedron Letters, , p. 5209 - 5212
反应条件
tetra-n-butylammonium fluoride trihydrate in diethyl ether
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C / |Inert atmosphere 2.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / |Inert atmosphere 2.2: 19 h / 20 °C / |Inert atmosphere View Scheme
参考文献
O'Rourke, Natasha F.; Wulff, Jeremy E.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1292 - 1308
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=100°C; 12 h;
参考文献
Shimada, Toyoshi; Mukaide, Kotaro; Shinohara, Akihiro; Han, Jin Wook; Hayashi, Tamio
Journal of the American Chemical Society, 2002 , vol. 124, # 8 p. 1584 - 1585
反应条件
copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; Sonogashira coupling;
参考文献
Gottardo, Christine; Aguirre, Andrea
Tetrahedron Letters, 2002 , vol. 43, # 39 p. 7091 - 7094
反应条件
zinc(II) chloride in 1,4-dioxane
T=100°C; 1.5 h;
参考文献
Andreev, Aleksey A.; Konshin, Valeri V.; Komarov, Nikolai V.; Rubin, Michael; Brouwer, Chad; Gevorgyan, Vladimir
Organic Letters, 2004 , vol. 6, # 3 p. 421 - 424
反应条件
zinc trifluoromethanesulfonate; triethylamine in dichloromethane
T=23°C; 12 h;
参考文献
Rahaim Jr., Ronald J.; Shaw, Jared T.
Journal of Organic Chemistry, 2008 , vol. 73, # 7 p. 2912 - 2915
反应条件
bis(triphenylphosphine)palladium(II)-chloride; copper monoiodide in triethylamine
参考文献
FMC Corporation
Patent: US5073564 A1, 1991 ;
反应条件
1: 4-trifluoromethyl phenylacetylene With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 2 h; Inert atmosphere;
2: chloro-trimethyl-silane in tetrahydrofuran; hexane
T=0 - 20°C;
参考文献
Miura, Katsukiyo; Inoue, Gen; Sasagawa, Hisashi; Kinoshita, Hidenori; Ichikawa, Junji; Hosomi, Akira
Organic Letters, 2009 , vol. 11, # 21 p. 5066 - 5069
反应条件
copper; isopentyl nitrite in acetonitrile
T=0 - 15°C; Sandmeyer Reaction; 8 h; Schlenk techniqueInert atmosphere;
参考文献
Dai, Jian-Jun; Fang, Chi; Xiao, Bin; Yi, Jun; Xu, Jun; Liu, Zhao-Jing; Lu, Xi; Liu, Lei; Fu, Yao
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8436 - 8439