1-[(三甲基硅基)乙炔基]-4-(三氟甲基)苯合成路线 （共 15 条）
反应条件
1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 18 h / 20 °C / |Schlenk technique; |Inert atmosphere
2: copper; isopentyl nitrite / acetonitrile / 8 h / 0 - 15 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Dai, Jian-Jun; Fang, Chi; Xiao, Bin; Yi, Jun; Xu, Jun; Liu, Zhao-Jing; Lu, Xi; Liu, Lei; Fu, Yao
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8436 - 8439
反应条件
Sonogashira Cross-Coupling;
参考文献
Chae, Yeong Mi; Bae, Jun Sung; Moon, Jong Hun; Lee, Jin Yong; Yun, Jaesook
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 843 - 849
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide
T=80°C; sila-Sonogashira reaction; 3 h;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
copper(l) chloride; palladium dichloride; tris(p-fluoro phenyl)phosphine in N,N-dimethyl-formamide
T=100°C; sila-Sonogashira-Hagihara cross-coupling; 12 h; Inert atmosphere;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
