N,N-二甲基-4-[(三甲基甲硅烷基)乙炔]苯胺合成路线 （共 8 条）
反应条件
1.1: 82 percent / tetrabutylammonium fluoride / tetrahydrofuran; H2O / 1 h / 0 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C 2.2: 57 percent / tetrahydrofuran; hexane / 0.33 h / -78 - 20 °C View Scheme
参考文献
Leonard, Kristi; Nelen, Marina; Raghu, Madhavi; Detty, Michael R.
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 3 p. 707 - 717
反应条件
potassium carbonate in methanol 2 h;
参考文献
Organic Letters, , vol. 5, # 11 p. 1841 - 1844
反应条件
copper(l) iodide; hydrogen; triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=20°C; Sonogashira coupling; 1 h;
参考文献
Elangovan, Arumugasamy; Wang, Yu-Hsiang; Ho, Tong-Ing
Organic Letters, 2003 , vol. 5, # 11 p. 1841 - 1844
反应条件
piperidine; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triphenylphosphine
8 h; Heating;
参考文献
Leonard, Kristi A.; Nelen, Marina I.; Anderson, Linda T.; Gibson, Scott L.; Hilf, Russell; Detty, Michael R.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3942 - 3952
反应条件
1: iodine / CHCl3 / 2 h / 20 °C
2: CuI; triethylamine; H2 / dichlorobis(triphenylphosphine)palladium(II) / 20 °C
View Scheme
参考文献
Elangovan, Arumugasamy; Chen, Ting-Yu; Chen, Chih-Yuan; Ho, Tong-Ing
Chemical Communications, 2003 , # 17 p. 2146 - 2147
反应条件
1.1: KOH / methanol; tetrahydrofuran / 4 h / 25 °C
2.1: 98 percent / Pd(PPh3)2Cl2; Et2NH; CuI / tetrahydrofuran / 24 h / 25 °C
3.1: KOH / methanol; tetrahydrofuran / 4 h / 25 °C
3.2: 0.39 g / Pd(PPh3)2Cl2; CuI; NHEt2 / tetrahydrofuran / 24 h / 25 °C
View Scheme
参考文献
Zhi, Yong-Gang; Lai, Siu-Wai; Chan, Queenie K.-W.; Law, Yuen-Chi; Tong, Glenna S.-M.; Che, Chi-Ming
European Journal of Organic Chemistry, 2006 , # 14 p. 3125 - 3139
反应条件
1: 95 percent / K2CO3 / methanol / 2 h
2: 2 percent / H2; CuI; piperidine / dichlorobis(triphenylphosphine)palladium(II) / acetonitrile / 8 h / Heating
View Scheme
参考文献
Elangovan, Arumugasamy; Wang, Yu-Hsiang; Ho, Tong-Ing
Organic Letters, 2003 , vol. 5, # 11 p. 1841 - 1844
反应条件
pyridine; copper diacetate; potassium carbonate in methanol; ethylene glycol dimethyl ether
Eglinton Coupling;
参考文献
Toyama, Takuya; Komori, Shizuka; Yoshino, Junro; Hayashi, Naoto; Higuchi, Hiroyuki
Tetrahedron Letters, 2013 , vol. 54, # 1 p. 66 - 71
