1,2,3,6-四氢-1-(苯基甲基)吡啶合成路线 （共 35 条）
参考文献
DuPont Pharmaceuticals Company
Patent: US5886191 A1, 1999 ;
反应条件
1: p-bromophenyl bromide With n-butyllithium in tetrahydrofuran; hexane T=-60 - -50°C; 0.333333 h; 2: 1-(phenylmethyl)-1,2,3,6-tetrahydropyridine in tetrahydrofuran; hexane T=20°C;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/192729 A1, 2004 ;
Location in patent: Page 33 ;
反应条件
hydrogenchloride in ethanol
参考文献
Wichitnithad, Wisut; O'Callaghan, James P.; Miller, Diane B.; Train, Brian C.; Callery, Patrick S.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7482 - 7492
反应条件
1: 93 percent / benzene / 1 h / Heating 2: NH2NH2*H2O; KOH / ethane-1,2-diol / 1.5 h / Heating 3: CHCl3 / 12 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 16 p. 4523 - 4526
参考文献
Dang, Zhao; Yang, Yushe; Ji, Ruyun; Zhang, Shuhua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4523 - 4526
反应条件
in dichloromethane T=23°C;
参考文献
Schramm, Heiko; Pavlova, Maria; Hoenke, Christoph; Christoffers, Jens
Synthesis, 2009 , # 10 art. no. T20608SS, p. 1659 - 1662
反应条件
1: 93 percent / benzene / 1 h / Heating 2: NH2NH2*H2O; KOH / ethane-1,2-diol / 1.5 h / Heating 3: CHCl3 / 12 h / 20 °C 4: 92 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Dang, Zhao; Yang, Yushe; Ji, Ruyun; Zhang, Shuhua
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4523 - 4526
反应条件
1: in toluene
T=20 - 110°C; 1 h;
2: With sodium tetrahydroborate; ethanol in toluene
T=20°C; 20.3333 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: US2011/166357 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
sodium tetrahydroborate
参考文献
Majchrzak, Michal; Kotelko, Antoni; Lambert, Joseph B.
Organic Magnetic Resonance, 1983 , vol. 21, # 9 p. 539 - 543
反应条件
camphor-10-sulfonic acid in water
T=100°C; 1 h;
参考文献
Mccann,S.F.; Overman,L.E.
Journal of the American Chemical Society, 1987 , vol. 109, p. 6107
