3-氨基-1H-吡唑啉酮[3,4-b]喹喔啉合成路线 （共 10 条）
反应条件
hydrogenchloride; sodium nitrite 1.) 0 deg C, 2.) water, 60 min; Yield given. Multistep reaction;
参考文献
Ortega, Miguel A.; Montoya, Maria E.; Zarranz, Belen; Jaso, Andres; Aldana, Ignacio; Leclerc, Sophie; Meijer, Laurent; Monge, Antonio
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2177 - 2184
反应条件
hydrazine hydrate
1 h; Heating;
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
1: 85 percent / PCl5, POCl3 / 1.5 h / 110 °C
2: 83 percent / ethanol / 0.5 h / Heating
View Scheme
参考文献
Yoshida, Kei; Otomasu, Hirotaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
反应条件
1: 89 percent / (NH4)2CO3 / methanol / Ambient temperature
2: 85 percent / PCl5, POCl3 / 1.5 h / 110 °C
3: 83 percent / ethanol / 0.5 h / Heating
View Scheme
参考文献
Yoshida, Kei; Otomasu, Hirotaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
反应条件
1: 93 percent / ethanol / 0.5 h / Heating
2: 0.03 g / PCl3 / 1 h / Heating
View Scheme
参考文献
Yoshida, Kei; Otomasu, Hirotaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
反应条件
1: 45 percent / POCl3 / dimethylformamide; toluene / 2 h / Heating
2: 93 percent / ethanol / 0.5 h / Heating
3: 0.03 g / PCl3 / 1 h / Heating
View Scheme
参考文献
Yoshida, Kei; Otomasu, Hirotaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
反应条件
phosphorus trichoride
1 h; Heating;
参考文献
Yoshida, Kei; Otomasu, Hirotaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3361 - 3365
反应条件
1: 2.) triethylamine / 1.) DMF, o deg C, 2.) DMF, 10 deg C, 4 h
2: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h
3: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h
4: 90 percent / hydrazine hydrate / 1 h / Heating
View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
1: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h
2: 90 percent / hydrazine hydrate / 1 h / Heating
View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
反应条件
1: 2.) sodium ditionate / 1.) methanol, 50 deg C, 2 h, 2.) ethanol, water, 50 deg C, 3 h
2: 1.) 35percent HCl, acetic acid, 2.) sodium nitrite / 1.) 4 deg C, 20 min, 2.) water, RT, 6 h
3: 90 percent / hydrazine hydrate / 1 h / Heating
View Scheme
参考文献
Monge; Palop; Pinol; Martinez-Crespo; Narro; Gonzalez; Sainz; Lopez De Cerain; Hamilton; Barker
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1135 - 1139
