3-[4-(4-甲氧基苯基)-1-哌嗪]-1-丙胺合成路线 （共 4 条）
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=20°C; 16 h; 2: With sodium hydroxide in diethyl ether
参考文献
UNIVERSITY OF KANSAS; THE SCRIPPS RESEARCH INSTITUTE; AUBE, Jeffrey; BOHN, Laura; PRISINZANO, Thomas, Edward; SCHOENEN, Frank, John; FRANKOWSKI, Kevin, John
Patent: WO2013/40321 A1, 2013 ;
Location in patent: Paragraph 00052 ;
反应条件
1: 94 percent / 1.) 55 deg C, 2 h, 2.) RT, overnight 2: 64 percent / LiAlH4 / diethyl ether / 9 h / Heating View Scheme
参考文献
UNIVERSITY OF KANSAS; THE SCRIPPS RESEARCH INSTITUTE; AUBE, Jeffrey; BOHN, Laura; PRISINZANO, Thomas, Edward; SCHOENEN, Frank, John; FRANKOWSKI, Kevin, John
Patent: WO2013/40321 A1, 2013 ;
反应条件
hydrazine hydrate in ethanol Reflux;
参考文献
Lee, Jie Eun; Koh, Hun Yeong; Seo, Seon Hee; Baek, Yi Yeon; Rhim, Hyewhon; Cho, Yong Seo; Choo, Hyunah; Pae, Ae Nim
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 14 p. 4219 - 4222
反应条件
1: 60 percent / K2CO3 / butan-1-ol / 25 h / Heating 2: 94 percent / 1.) 55 deg C, 2 h, 2.) RT, overnight 3: 64 percent / LiAlH4 / diethyl ether / 9 h / Heating View Scheme
参考文献
Valenta, Vladimir; Vlkova, Marie; Holubek, Jiri; Svatek, Emil; Metysova, Jirina; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 3 p. 797 - 808
