[1,1-双(羟基甲基)-3-(4-辛基苯基)丙基]氨基甲酸苯基甲酯合成路线 （共 3 条）
反应条件
sodium hydrogencarbonate in chloroform
T=20°C; 18 h;
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Tomatsu, Ayumi; Chino, Masao; Takeda, Shuzo; Tanaka, Yoshihito; Maeda, Yasuhiro; Sato, Noriko; Mitsutomi, Naoko; Sugahara, Kunio; Chiba, Kenji
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 425 - 432
反应条件
potassium hydrogencarbonate in water; ethyl acetate
T=20°C; Schotten-Baumann reaction; 2 h;
参考文献
Hale, Jeffrey J.; Yan, Lin; Neway, William E.; Hajdu, Richard; Bergstrom, James D.; Milligan, James A.; Shei, Gan-Ju; Chrebet, Gary L.; Thornton, Rosemary A.; Card, Deborah; Rosenbach, Mark; Hughrosen; Mandala, Suzanne
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 18 p. 4803 - 4807
反应条件
1.1: 99 percent / immobilized lipase / tetrahydrofuran / 16 h / 20 °C
2.1: 1H-tetrazole / acetonitrile; CH2Cl2 / 1 h / 0 °C
2.2: 99 percent / mCPBA / acetonitrile; CH2Cl2 / 0.33 h / 0 °C
3.1: 76 percent / H2 / Pd-C / methanol / 7 h
View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Tomatsu, Ayumi; Chino, Masao; Takeda, Shuzo; Tanaka, Yoshihito; Maeda, Yasuhiro; Sato, Noriko; Mitsutomi, Naoko; Sugahara, Kunio; Chiba, Kenji
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 425 - 432
